Results 121 to 130 of about 2,506,502 (302)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Japan road map 1:1,000,000 [cartographic material]/
, 1945 Various eds. Road map series of Japan and Korea showing transportation, water features and populated places. Relief shown by shading and spot heights.; Standard map series designation: [Series] A.M.S.
United States. Army Map Service.
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 1921 Map shows oil and gas drilling and producing activity; oil and gas fields, pipelines, pump stations, well ownership, railroads, counties, and towns. Includes legend, indexes, and key to geological formations. Insets: "U.S.G.S.
Oil City Map Co.
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Clason's Guide to Texas: With Map of Auto Routes
, 1917 Map of the state of Texas and surrounding areas. Individual counties are outlined in green and labeled with roads marked in red and railroads marked in black. Geographic features are marked with relief shown by hachures.
Clason Map Co.
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Erratum: 2D map projections for visualization and quantitative analysis of 3D fluorescence micrographs. [PDF]
Sci Rep, 2015 Hernán Sendra G +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Truk Islands [cartographic material] : special strategic map /
, 1962 Ed. 1-AMS. Map of the Chuuk Islands region in the north Pacific Ocean. Relief shown by spot heights.; Compiled "February 1943."; "2-62."; Also available online http://nla.gov.au/nla.map-vn5748169.Title in upper margin: Special strategic map 1:1,000 ...
United States. Army Map Service.
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source