Results 131 to 140 of about 8,279 (296)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Els mapes conceptuals per a la representació de la cultura moral dels centres educatius

open access: yesTemps d'Educació, 2007
El presente artículo parte del supuesto de que la cultura moral de los centros educativos es uno de los principales agentes en la formación de sus miembros.
Laura Rubio i Serrano
doaj  

Steven Mapes, tuba

open access: yes, 1994
Edward GregsonAntonio CapuzziMatthias BamertRichard ...

core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Visual Understanding Environment : una eina automàtica per generar i gestionar mapes conceptuals

open access: yesBiD: Textos Universitaris de Biblioteconomia i Documentació, 2011
Es descriuen noves eines que ajuden en les diferents fases del cicle de vida de la recerca i de la gestió bibliogràfiques. En concret es descriu una situació en què s'ha fet servir Zotero com a complement de Firefox, juntament amb Visual Understanding ...
Baz, Joan V.
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Codificació de Mapes de Profunditat per 3DTV

open access: yes, 2016
En aplicacions de 3D TV, l'elevat nombre de diferents vistes (càmeres) fa que la quantitat de dades a enviar sigui molt elevada. A més, per poder tenir aplicacions de Free View Point Video, sovint s'envien també els mapes de profunditat associats a cada ...
Sañas Alier, Miquel
core   +1 more source

Spatializing Authenticity: The Scaled (Micro-)landscapes in/of Brooklyn Restaurants

open access: yes, 2019
Building on work concerning the "scaling of taste" (Silverstein 2016) and the hierarchical ordering of people, objects, and place (e.g. T rinch and Snajdr 2017), this paper orients specifically to language materiality and political economy (Cavanaugh ...
Mapes, Gwynne Erin
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

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