Results 1 to 10 of about 106 (86)

maplet: an extensible R toolbox for modular and reproducible metabolomics pipelines. [PDF]

Bioinformatics, 2022
Abstract   This article presents maplet, an open-source R package for the creation of highly customizable, fully reproducible statistical pipelines for metabolomics data analysis. It builds on the SummarizedExperiment data structure to create a centralized pipeline framework for storing data, analysis
Chetnik K, Benedetti E, Gomari DP, Schweickart A, Batra R, Buyukozkan M, Wang Z, Arnold M, Zierer J, Suhre K, Krumsiek J.   +10 more
europepmc   +5 more sources

The landscape of metabolic brain alterations in Alzheimer's disease. [PDF]

Alzheimers Dement, 2023
Abstract Introduction Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD‐associated metabolic changes in the brain has been missing. Methods We metabolically profiled 500 samples from the dorsolateral prefrontal cortex.
Batra R, Arnold M, Wörheide MA, Allen M, Wang X, Blach C, Levey AI, Seyfried NT, Ertekin-Taner N, Bennett DA, Kastenmüller G, Kaddurah-Daouk RF, Krumsiek J, Alzheimer's Disease Metabolomics Consortium (ADMC).   +13 more
europepmc   +2 more sources

Butterfly Diversity and Community Dynamics in the Central Himalayas: Species Composition, Richness, Abundance, and Seasonal Variation of Butterflies (Lepidoptera: Papilionoidea) in Bhorletar, Nepal. [PDF]

Ecol Evol
This study presents an assessment of butterfly diversity in the foothills of Bhorletar, Lamjung District, Nepal, documenting 226 species across 129 genera and six families. The research reveals a bimodal pattern of species richness, peaking in April and August, with significant implications for conservation and management strategies.
Kc S, Sapkota A.
europepmc   +2 more sources

An Untapped and Undocumented Butterfly Diversity in a Rapidly Urbanizing and Fragmenting Forest Habitat in Pokhara, Nepal: First Checklist and Implications for Conservation and Ecotourism. [PDF]

Ecol Evol
Documenting indicator taxa such as butterflies is crucial in biodiversity hotspots such as the Himalayas, particularly in rapidly urbanizing areas such as Pokhara, Nepal. This study recorded 225 butterfly species in the Methlang Forest area of Lakeside, Pokhara, including new and long‐absent national records.
Kc S.
europepmc   +2 more sources

Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer's disease and progressive supranuclear palsy. [PDF]

Alzheimers Dement
Abstract BACKGROUND Metabolic dysregulation is a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD) and progressive supranuclear palsy (PSP). Although metabolic dysregulation is a common link between these two tauopathies, a comprehensive brain metabolic comparison of the diseases has not yet been performed.
Batra R, Krumsiek J, Wang X, Allen M, Blach C, Kastenmüller G, Arnold M, Ertekin-Taner N, Kaddurah-Daouk R, Alzheimer's Disease Metabolomics Consortium (ADMC).   +9 more
europepmc   +2 more sources

Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Increasing evidence suggests that metabolic impairments contribute to early Alzheimer's disease (AD) mechanisms and subsequent dementia. Signals in metabolic pathways conserved across species can facilitate translation. METHODS We investigated differences in serum and brain metabolites between the early‐onset 5XFAD and late‐onset ...
Pandey RS, Arnold M, Batra R, Krumsiek J, Kotredes KP, Garceau D, Williams H, Sasner M, Howell GR, Kaddurah-Daouk R, Carter GW.   +10 more
europepmc   +2 more sources

Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The molecular mechanisms that contribute to sex differences, in particular female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and pathology, are incompletely understood. METHODS To address this problem, we investigated cellular metabolism and immune responses (“immunometabolism endophenotype”) across AD ...
Hou Y, Caldwell JZK, Lathia JD, Leverenz JB, Pieper AA, Cummings J, Cheng F.   +6 more
europepmc   +2 more sources

Maplet programada via maple: solução numérica de um PVI utilizando os Métodos Lineares de passo múltiplo explícitos

Vetor, 2016
Este artigo objetiva divulgar uma Maplet programada via Maple 16 para resolver um Problema de Valor Inicial composto por uma Equação Diferencial Ordinária de Primeira Ordem utilizando os Métodos Lineares de Passo Múltiplo Explícitos.
Adilandri Mércio Lobeiro, Oilson Alberto Gonzatto Junior, Tereza Maria Pereira Garcia, Liliana Madalena Gramani, Eloy Kaviski   +4 more
doaj   +5 more sources

On Maplet Development And Programming Tutorial For Science And Engineering Students [PDF]

2010 Annual Conference & Exposition Proceedings, 2020
Comment: 23 ...
Aarti Narayanan, Ganapathy Narayanan
openaire   +2 more sources

Maplets: An Efficient Approach for Cooperative SLAM Map Building Under Communication and Computation Constraints [PDF]

2020 IEEE/ION Position, Location and Navigation Symposium (PLANS), 2020
This article introduces an approach to facilitate cooperative exploration and mapping of large-scale, near-ground, underground, or indoor spaces via a novel integration framework for locally-dense agent map data. The effort targets limited Size, Weight, and Power (SWaP) agents with an emphasis on limiting required communications and redundant ...
Kevin M. Brink, Ryan E. Sherrill, Jamie L. Godwin, Jincheng Zhang, Andrew R. Willis   +4 more
openaire   +2 more sources