A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Rodinga, Northern Territory [cartographic material] : Commonwealth Topographic Survey /
, 1960 Provisional ed. Topographic map of Rodinga region, Northern Territory, showing classes of roads, railway and telephone lines, fences, state boundries, watercourses and dams, and windpumps. Relief shown by spot heights.; "Compilation: Division of National
Australia. Division of National Mapping.
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The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
PDBe-SIFTS: An open-source tool for Structure Integration with Function, Taxonomy, and Sequences, featuring improved alignment, scoring scheme, and accelerated search. [PDF]
Protein SciBellaiche A +10 more
europepmc +1 more source
Singapore 1:25,000 road map [cartographic material] /
, 1980 Ed. 3 SMU. Shows selected buildings, points of interest, and schools.; Base information, aerial photography dated Jan. 1974, Aug. 1979 and partial ground verification up to Jan. 1980.; "R.S.O. metric grid."; Some sheets include insets.; Includes lists of
Singapore. Ministry of Defence. Mapping Unit.
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Accelerating Chemical Potential Calculations with Minimal Normalizing Flows. [PDF]
J Chem Theory ComputBaron PB, Panagiotopoulos AZ.
europepmc +1 more source
Victoria River Downs, Northern Territory [cartographic material] : Commonwealth topographic survey /
, 1960 Provisional ed. Topographic map of Victoria River Downs region, Northern Territory showing classes of roads, railway and telephone lines, mines, post offices, wireless transceivers, windpumps, airports or airfields and landing grounds, horizontal control
Australia. Division of National Mapping.
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Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Advanced Imaging of the Right Heart and Pulmonary Circulation: The Role of Echocardiography and Cardiovascular Magnetic Resonance. [PDF]
J Clin MedKościuk M, Kaminski KA, Kazimierczyk R.
europepmc +1 more source