End‐of‐Life Loneliness, Social Isolation, and Symptom Burden: A Nationally‐Representative Study
ABSTRACT Background Loneliness (subjective feeling of lacking connection) and social isolation (objective deficit in number of relationships or contact with others) are common at the end‐of‐life and can be detrimental to quality of life. Investigating the association between symptoms and end‐of‐life loneliness and social isolation could help inform ...
Mara Rosenberg +3 more
wiley +1 more source
Longer duration of intact hypothalamic-pituitary-gonadal (HPG) axis buffers the adverse impact of late-life frailty in male dogs. [PDF]
Waters DJ +6 more
europepmc +1 more source
Development of a Video‐Based Decision Aid for Breast Cancer Screening Among Older Women
ABSTRACT Background Whether to continue breast cancer screening beyond age 74 is uncertain. Decision aids may improve understanding of health information and support informed screening decisions. The goal of this study was to develop a video‐based decision aid for breast cancer screening among older women using patient‐centered design.
Meghan E. Lindsay +6 more
wiley +1 more source
Predictors of Cyclophosphamide Resistance in Granulomatosis with Polyangiitis: A Retrospective Cohort Study. [PDF]
Dağlı PA +14 more
europepmc +1 more source
Three‐case restricted two‐stage multi‐locus multi‐allele genome‐wide association study identified main‐effect genes and detected the regulatory effects of intergenic loci on genes, enabling comprehensive dissection of the genic‐intergenic genetic system for quantitative traits and providing a strategy for studying their genetic basis.
Xiaoshuai Hao +11 more
wiley +1 more source
Intermittent Fasting Ameliorates Testicular Damage via Oxidative Stress Modulation in a Genetic Absence Epilepsy Rat Model. [PDF]
Gökçeoğlu Kayalı D +9 more
europepmc +1 more source
Disabling a conserved module confers broad‐spectrum resistance
This commentary reviews the discovery by Yuan et al. of a conserved susceptibility module where fungal Gas2 stabilizes host SnRK1β1A to suppress nuclear immunity in rice. It discusses the mechanism for broad‐spectrum resistance via genome editing and considers the essential balance between enhanced defense and associated agronomic trade‐offs.
Zhen Zeng +3 more
wiley +1 more source
"I Started Avoiding It, What's the Point?": Intimate Partner Violence Survivors' Stories of Medical Disenfranchisement. [PDF]
Maras SA.
europepmc +1 more source
Chicken or egg? The evolutionary riddle of CMS and Rf in plants
Cytoplasmic male sterility (CMS) reduces pollen fertility and nuclear Rf genes restore fertility. This Commentary explores support for the “arms race” and “pre‐adaptation” models for CMS–Rf co‐evolution. CMS and Rf interact dynamically, influencing plant reproduction, stress tolerance, and hybrid seed production, highlighting co‐evolutionary processes ...
Peilin Wang +4 more
wiley +1 more source
Patient-Physician Discordance and Unmet Needs in Rheumatoid Arthritis: A Network Analysis of Clinical and Quality-of-Life Domains. [PDF]
Akan S +6 more
europepmc +1 more source

