Results 1 to 10 of about 366,587 (171)
Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology. [PDF]
Pediatr Allergy ImmunolThis graphical abstract demonstrates a “rare‐to‐common” translational pipeline. Insights from rare monogenic conditions reveal key mechanisms of immune dysregulation. This knowledge informs the understanding of polygenic common allergic diseases, which share overlapping pathogenic pathways.
Castagnoli R +26 more
europepmc +2 more sources
Revista Gestão e Desenvolvimento, 2007 As contínuas mudanças no cenário competitivo motivam a busca de novas estratégias, por parte das empresas, para garantir a sua permanência no mercado. As transformações ocorridas no cenário político, econômico e social impactaram diretamente no ambiente
Cristiane Froehlich, Leonardo Neumann
doaj +5 more sources
PASOS Revista de Turismo y Patrimonio Cultural, 2021 Nas últimas décadas o conceito de marca tem sido associado ao turismo, funcionando como uma ferramenta de marketing. Os destinos turísticos passaram a ser vistos como empresas e começam a utilizar a marca como forma de atrair e fidelizar o visitante. A
Hugo Manuel Oliveira Martins +3 more
doaj +1 more source
International Journal of Cancer, Volume 153, Issue 3, Page 584-599, 1 August 2023., 2023 What's new? The tumoricidal complex alpha1‐oleate is active as a bladder cancer therapeutic and has shown efficacy in patients without evidence of toxicity. Here, the authors tested whether repeated treatment with alpha1‐oleate, combined with low‐dose chemotherapy, would improve long‐term treatment efficacy.
Tran Thi Hien +8 more
wiley +1 more source
Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route
Journal of Nanotechnology, Volume 2023, Issue 1, 2023., 2023 Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid‐induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid carriers (NLCs) have emerged as a promising delivery carrier ...
Alok Kumar Mahor +11 more
wiley +1 more source
Early Medieval Europe, Volume 30, Issue 4, Page 536-557, November 2022., 2022 Around 1000, a new type of law‐book emerged in Catalonia and northern Italy that attests to new ways of handling legal material. Incorporating in full the Visigothic and Lombard law codes, respectively, these law‐books provided a base for studying and interpreting old law through comments, glosses etc., addressing new users such as lay judges.
Stefan Esders
wiley +1 more source
Gut tissue‐resident memory T cells in coeliac disease
Scandinavian Journal of Immunology, Volume 95, Issue 1, January 2022., 2022 Abstract This mini‐review describes observations of the 1990ies with culturing of gluten‐specific and astrovirus‐specific CD4+ T cells from duodenal biopsies from subjects who presumably had a long time between the exposure to gluten or astrovirus antigens and the sampling of the biopsy. In these studies, it was also observed that antigen‐specific CD4+
Ludvig M. Sollid
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Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver
European Journal of Immunology, Volume 51, Issue 11, Page 2568-2575, November 2021., 2021 Di Censo et al. identified distinct ILC1 populations in the mouse liver, defined by the expression of granzyme A (GzmA) and CD160. Expression of these molecules is finely tuned perinatally and delineates ILC1 with graded ability to produce IFN‐γ and to kill cancer cells.
Chiara Di Censo +27 more
wiley +1 more source
Contextus, 2011 Este estudo tem como foco a indústria calçadista. O objetivo central do artigo está em analisar os fatores motivadores e restritivos da indústria do calçado em fornecer marcas próprias aos varejistas. Através do método de estudo de casos múltiplos, foram
Alessandra Cristófoli de Lima +3 more
doaj +1 more source
Know your enemy or find your friend?—Induction of IgA at mucosal surfaces
Immunological Reviews, Volume 303, Issue 1, Page 83-102, September 2021., 2021 Abstract Most antibodies produced in the body are of the IgA class. The dominant cell population producing them are plasma cells within the lamina propria of the gastrointestinal tract, but many IgA‐producing cells are also found in the airways, within mammary tissues, the urogenital tract and inside the bone marrow. Most IgA antibodies are transported
Mats Bemark, Davide Angeletti
wiley +1 more source