Results 91 to 100 of about 34,203 (293)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Unveiling Alkali‐Induced Redox Modulation: In‐Situ Spectroscopic Insights from RWGS on Alkali‐Modified ZrO2‐Supported Cu Catalysts

Advanced Science, EarlyView.
Revisiting the prevailing views that alkali only enhances adsorption properties and stabilizes metal particles against sintering, this study highlights the key role of Na+ in modulating Cu redox properties. Na+ added via wet impregnation (WI) hinders Cu2+ reduction but promotes oxidation and leads to Cu site loss by sintering/coverage. In contrast, the
Abdallah I. M. Rabee, Thanh Huyen Vuong, Laura Kraußer, Hayder Abed, Hanan Atia, Nils Rockstroh, Henrik Lund, Stephan Bartling, Evgenii V. Kondratenko, Angelika Brückner, Jabor Rabeah   +10 more
wiley   +1 more source

Muscle Inflammation Susceptibility: A Potential Phenotype for Guiding Precision Rehabilitation After Total Hip Arthroplasty in End-Stage Osteoarthritis. [PDF]

HSS J, 2023
Bridges SL, Sun D, Graham ZA, McAdam JS, Mayo ED, Bamman MM.   +5 more
europepmc   +1 more source

Bandgap‐Dependent Doping of Semiconducting Carbon Nanotube Networks by Proton‐Coupled Electron Transfer for Stable Thermoelectrics

Advanced Electronic Materials, EarlyView.
Proton‐coupled electron transfer doping with benzoquinone is applied to p‐dope dense films of semiconducting single‐walled carbon nanotubes. The doping efficiency depends on the pH of the doping solution and the bandgap of the nanotubes. The highest conductivities and power factors are achieved for small‐bandgap nanotubes, remaining stable for over 120
Angus Hawkey, Xabier Rodríguez‐Martínez, Sebastian Lindenthal, Moritz C. F. Jansen, Reverant Crispin, Jana Zaumseil   +5 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Assistentes virtuais de marca como reforço dos estereótipos e preconceitos

, 2023
Gisela G. S. Castro, Marcos Hiller
openalex   +2 more sources

El metaverso: ¿Un mundo virtual para generar conexiones con la marca? Caso: Nikeland [PDF]

, 2022
Raiza Lizandra Villanueva Ayala
openalex   +1 more source

Thermoelectric Properties of a Family of Benzodifuranone‐Based Conjugated Copolymers in Oriented Thin Films Doped Sequentially With NDMBI‐H

Advanced Electronic Materials, EarlyView.
Combining high polymer orientation of n‐type copolymers by temperature rubbing and sequential doping with N‐DMBI results in a strong improvement of electrical conductivity and thermoelectric power factors reaching up to 9.8 ± 1.6 S cm−1 and 8 ± 3 µW m−1.K2, respectively.
Shubhradip Guchait, Diego R. Hinojosa, Nathan James Pataki, Said Oummouch, Laurent Herrmann, Mario Caironi, Michael Sommer, Martin Brinkmann   +7 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

RÉGIMEN JURÍDICO DEL USO DE LA MARCA EN LA PUBLICIDAD

, 2018
Nuria Martínez Sánchez
openalex   +2 more sources