Results 91 to 100 of about 825,995 (254)
HSCT mission analysis of waverider designs [PDF]
In the second quarter the development of the two waverider design tools was continued, and the groundwork necessary for the incorporation of waverider technology into the realm of the High Speed Civil Transports (HSCT's) was laid out. Advances in each of
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Advanced Science, EarlyView.PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao +6 more
wiley +1 more source
Further development of a method for computing three-dimensional subsonic viscous flows in turbofan lobe mixers [PDF]
Procedure for computing subsonic, turbulent flow in turbofan lobe mixers was extended to allow consideration of flow fields in which a swirl component of velocity may be present.
Briley, W. R. +3 more
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PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
Advanced Science, EarlyView.This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang +13 more
wiley +1 more source
User's manual for PEPSIG NASA tip vortex version [PDF]
The tip vortex flowfield plays a significant role in the performance of advanced aircraft propellers. The flowfield in the tip region is complex, three-dimensional and viscous with large secondary velocities.
Dejong, Frederick J. +2 more
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Advanced Science, EarlyView.We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta +7 more
wiley +1 more source
Extended mapping and characteristics techniques for inverse aerodynamic design [PDF]
Some ideas for using hodograph theory, mapping techniques and methods of characteristics to formulate typical aerodynamic design boundary value problems are developed.
Qian, Y. J., Sobieczky, H.
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Advanced Science, EarlyView.This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu +7 more
wiley +1 more source
Derivation and evaluation of an approximate analysis for three-dimensional viscous subsonic flow with large secondary velocities [PDF]
An approximate analysis is presented for calculating three-dimensional, low Mach number, laminar viscous flows in curved passages with large secondary flows and corner boundary layers.
Anderson, O. L. +2 more
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NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source