Results 231 to 240 of about 456,887 (304)

Late‐Stage Modification of Halotryptophan‐Containing Peptides Via Negishi Cross‐Coupling

open access: yesChemistry – A European Journal, EarlyView.
Negishi cross‐coupling provides access to the late‐stage functionalization of bromotryptophan‐containing peptides under comparatively mild conditions and is applicable to a range of peptide substrates in the investigated model systems. The examined alkyl iodides and variation of N‐terminal residues demonstrate the feasibility of the transformation in a
Laura Cerveson   +2 more
wiley   +1 more source

EVALUATION OF CLINICAL ASPECTS OF PATIENTS UNDERGOING SACRAL NEUROMODULATION FOR FECAL INCONTINENCE: A RETROSPECTIVE MULTICENTER STUDY. [PDF]

open access: yesArq Gastroenterol
Camargo HP   +14 more
europepmc   +1 more source

Rank‐based estimation of propensity score weights via subclassification

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Propensity score (PS) weighting estimators are widely used for causal effect estimation and enjoy desirable theoretical properties, such as consistency and potential efficiency under correct model specification. However, their performance can degrade in practice due to sensitivity to PS model misspecification.
Linbo Wang   +3 more
wiley   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

open access: yesCytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham   +3 more
wiley   +1 more source

Characterization and Antifungal Activity of Essential oil of Cymbopogon citratus: Special Emphasis on Preliminary Fungicidal Mechanisms against Candida auris and Cryptococcus neoformans. [PDF]

open access: yesCurr Microbiol
Gurgel do Amaral Valente Sá L   +15 more
europepmc   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović   +11 more
wiley   +1 more source

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