Margarite Yourcenar:el método histórico y la literatura
El artículo presenta a Margarite Yourcenar como una literata que utiliza métodosde la investigación histórica en la edificación de toda su obra: la autora se planteaproblemas históricos y elabora hipótesis de trabajo sobre sus temas a través delestudio ...
César Augusto Ayala Diago
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Unique evidence of fluid alteration in the Kakowa (L6) ordinary chondrite [PDF]
Meteorites preserve evidence of processes on their parent bodies, including alteration, metamorphism, and shock events. Here we show that the Kakowa (L6) ordinary chondrite (OC) preserves both shock-melt veins and pockets of detrital grains from a ...
I. P. Baziotis +8 more
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Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy [PDF]
Triple-negative breast cancers (TNBCs) are aggressive forms of breast cancer and tend to grow and spread more quickly than most other types of breast cancer.
Shengli Dong +6 more
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Occurrence and mineralogy of the margarite- and muscovite-bearing pseudomorphs after topaz in the Juurakko pegmatite, Orivesi, southern Finland [PDF]
Margarite- and muscovite-bearing pseudomorphs after topaz are described from the Juurakko pegmatite dyke, Orivesi, southern Finland. A supercritical vapour phase rich in calcium and alkalies caused alteration of topaz and some other silicates during ...
S.I. Lahti
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Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue [PDF]
Solid tumor progression is significantly influenced by interactions between cancer cells and the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to ECM fiber alignment and collagen deposition impact tumor growth and ...
Rakesh Gurrala +13 more
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Coaching People with Cardiovascular Disease to Close Their “Treatment Gaps” Reduces Hospital Utilization, Saves Lives, and Delivers Net Cost Savings Over 10 Years [PDF]
Background: Disease management programs are an essential tool in the fight against rising prevalence and costs associated with cardiovascular disease (CVD).
Joshua Byrnes +4 more
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Correction: Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor. [PDF]
[This corrects the article DOI: 10.1371/journal.pone.0226464.].
Tiffany C Chang +15 more
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Liver Kinase B1 Regulates Remodeling of the Tumor Microenvironment in Triple-Negative Breast Cancer [PDF]
Liver kinase B1 (LKB1) is a potent tumor suppressor that regulates cellular energy balance and metabolism as an upstream kinase of the AMP-activated protein kinase (AMPK) pathway.
Connor T. King +15 more
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Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling [PDF]
Extracellular signal-regulated kinase (ERK5) is an essential regulator of cancer progression, tumor relapse, and poor patient survival. Epithelial to mesenchymal transition (EMT) is a complex oncogenic process, which drives cell invasion, stemness, and ...
Akshita B. Bhatt +7 more
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Ceritinib is a novel triple negative breast cancer therapeutic agent [PDF]
Background Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype.
Shengli Dong +8 more
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