Results 201 to 210 of about 58,996 (259)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Effect of blood and artificial saliva contamination on marginal adaptation and sealing ability of different retrograde filling materials: A comparative analysis. [PDF]

J Conserv Dent Endod
Sunanda YL, Parvathaneni KP, Raju TBVG, Seshadri A, Dondapati GD.   +4 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

The internal and marginal adaptation of lithium disilicate endocrowns fabricated using intra and extraoral scanners: An in-vitro study. [PDF]

PLoS One
Akhlaghian M, Khaledi AA, Mosaddad SA, Dabiri S, Giti R, Kadkhodae F, Gholami S.   +6 more
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Impact of gamma radiation on marginal adaptation of nanohybrid composite and composition of dental hard tissues - Scanning electron microscopy and X-ray diffraction analysis: An in vitro pilot study. [PDF]

J Conserv Dent Endod
Bansal D, Bansal RK, Dora TK, Bansal M, Garg R, Kaur M.   +5 more
europepmc   +1 more source

The effect of two preparation designs on the fracture resistance and marginal adaptation of two types of ceramic crowns using CAD/CAM technology (In vitro study). [PDF]

BMC Oral Health
Ashour AM, El-Kateb MM, Azer AS.
europepmc   +1 more source

Comparative evaluation of marginal adaptation and fatigue resistance of endodontically treated premolars restored with direct and indirect coronal restorations: an in vitro study. [PDF]

BMC Oral Health
Rohym SM, Badra H, Nassar H.
europepmc   +1 more source

Internal fit and marginal adaptation of all-ceramic implant-supported hybrid abutment crowns with custom-milled screw-channels on Titanium-base: in-vitro study. [PDF]

BMC Oral Health
Fakhr MWZF, Alansary H, Hassanien EEY.
europepmc   +1 more source

Marginal adaptation of bulk-fill resin composites with different viscosities in class II restorations: a micro-CT evaluation. [PDF]

BMC Oral Health
Baltacioğlu İH, Demirel G, Öztürk B, Aydin F, Orhan K.   +4 more
europepmc   +1 more source