Results 41 to 50 of about 740,190 (301)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Journal of Dental SciencesBackground/purpose: Resin-based materials fabricated using digital light processing (DLP) have received increasing attention for use in permanent dental restorations.
Pei-Wen Peng +7 more
doaj +1 more source
Probability in Biology: The Case of Fitness [PDF]
, 2012 I argue that the propensity interpretation of fitness, properly understood, not only solves the explanatory circularity problem and the mismatch problem, but can also withstand the Pandora’s box full of problems that have been thrown at it.
Millstein, Roberta L.
core
, 2023 The Canada fitness survey was established to obtain: - fitness norms for persons aged 7 to 69 - baseline information and trends on activity patterns - baseline information and trends on other factors influencing fitness - trends in ...
Canada Fitness and Amateur Sport, Statistics Canada.
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Marginal Fit of All-Ceramic Crown. Marginal Fit at Each Fabrication Step for Staining Technique.
Nihon Hotetsu Shika Gakkai Zasshi, 1997 This study was conducted to investigate how the ideal marginal fit of wax crown changes through the injecting, staining, glazing, and cementing procedures during fabrication of the IPS Empress crownby the staining technique for the upper first premolar tooth of the Dental Study Model (500 A, NISSIN DENTAL PRODUCTS, Japan).
openaire +3 more sources
Kansas Fitness Week, May 1-9, 1982 : fitness is for everybody
, 1982 "Sponsored by the Governor's Council on Fitness"--Page 6Fitness is for Every Body -- Kansas Fitness Week May 1-9, 1982 -- Celebrate Fitness -- Governor's Cup Running Events -- Capitol Runs -- Regional Runs -- Guidelines to Success -- 1981 Project Sites --
Governor's Council on Fitness
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source