Results 61 to 70 of about 2,011,929 (253)

Effect of thermomechanical aging on marginal fit of three CAD-CAM restorative materials: An in vitro study [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects
Background. The present study assessed the impact of thermomechanical aging on the marginal fit of hybrid ceramic, reinforced composite resin, and lithium disilicate ceramic. Methods. Eighteen human upper first premolars freshly extracted for orthodontic
Reda Eid Attia, Hussein Ramadan Mohammed, Khaled Mohamed Haggag   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Comparing Marginal Fit and Marginal Gap between Sholder Bevel and 135° Finish Line Designs in Posterior Metal Ceramic Restoration Crowns

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: One of the major challenges for dentists is providing the patients with a crown of appropriate marginal fit and marginal gap. Preparation of a 135° finish line has some advantages such as technical ease and appropriate finish line
Tahmineh Bamdadian, Mohammad Ebrahimi Saravi, Farhad Sobouti, Pooya Jannati, Sahar Cheperli, Jamshid Yazdani Charati, Nasrin Khaki   +6 more
doaj  

Evaluation of marginal gap of Ni-Cr copings made with conventional and accelerated casting techniques

Indian Journal of Dental Research, 2013
Context: Conventional casting techniques following the manufacturers′ recommendations are time consuming. Accelerated casting techniques have been reported, but their accuracy with base metal alloys has not been adequately studied.
Pavan Kumar Tannamala, Nagarasampatti Sivaprakasam Azhagarasan, K Chitra Shankar   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Controlled Lateral Pressure on Cortical Bone Using Blade-Equipped Implants: An Experimental Study in Rabbits

Bioengineering
Background: This study aimed to evaluate the biological behavior of a novel implant design incorporating decompressive cervical blades. Hence, the aim of the present study was to evaluate the healing outcomes in cortical regions where decompressive ...
Vitor Ferreira Balan, Mauro Ferri, Eduardo Pires Godoy, Leticia Gabriela Artioli, Daniele Botticelli, Erick Ricardo Silva, Samuel Porfirio Xavier   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

مقایسه گپ داخلی مارژین در دو روش ساخت کوپینگ‏ های این سرام [PDF]

Journal of Mashhad Dental School, 2010
مقدمه: پرسلن‏های دندانی نقش بسیار مهمی در ساخت زیباترین رستوریشن‏های ثابت دارند. ترانسلوسنسی و عبور نور و سازگاری بیولوژیک، سرامیک‏های دندانی را در شمار مطلوب‏ترین مواد ترمیمی قرار داده است و در این میان عرضه سیستم این سرام تحولی بزرگ در ترمیم‏ها به شمار
اعظم السادات مدنی, محمدرضا صابونی, مهدی صدفی, فهیمه ارجمندی   +3 more
doaj