Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
Improving Nursing Care in Long-Term Care Facilities for Older Adults by Addressing the Social Diversity of the Nursing Staff. [PDF]
Roitenberg N.
europepmc +1 more source
Navigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation
LipidXplorer is a novel microfluidic platform which enables rapid navigation of lipid particle design space for high‐resolution phase mapping, lipid nanoparticle optimization, membrane biophysics, and functional nanomaterial discovery. It combines programmable composition control, continuous nanoparticle formation, and automated well‐plate collection ...
Bradley Diggines +10 more
wiley +1 more source
The Central-Periphery Hypothesis Revisited: Implications for Long-Term Genetic Conservation. [PDF]
Verbylaitė R +9 more
europepmc +1 more source
Mechanistically Interpretable Artificial Intelligence for Designing Oxygen Electrocatalysts
Mechanistically interpretable artificial intelligence screens nearly seven million perovskite compositions and identifies key descriptors—d‐p hybridization and densification resistance—that govern oxygen electrocatalysis. The discovered BaCo0.8Nb0.1Zr0.1O3‐δ achieves a record 2.68 W cm−2 peak power density at 600°C with over 500 h of durable operation ...
Xueyu Hu +15 more
wiley +1 more source
Ionic conjugated polyelectrolyte electron‐blocking layers enable photomultiplication organic photodetectors with dark current robustness up to −10 V and external quantum efficiencies exceeding 3000%. Fowler–Nordheim tunneling, interfacial dipole, trap density of states, and noise analyses reveal how ionic conjugated polyelectrolytes suppress electron ...
Yelim Kang +12 more
wiley +1 more source
The Social Response to Survivors of Attempted Intimate Partner Homicide. [PDF]
Avieli H.
europepmc +1 more source
A Family of Sodium Solid‐State Electrolytes Based on the NaGaxAl1‐xCl4 Solid Solution
ABSTRACT Sodium‐based metal chloride solid electrolytes are promising for sodium solid‐state batteries due to their excellent oxidation stability, which, as shown for Li halides, can coexist with high ionic conductivity. To explore cationic substitution effects, we synthesized NaGaxAl1‐xCl4 (0 ≤ x ≤ 1) via ball milling and investigated structural and ...
Hao Guo, Matteo Bianchini
wiley +1 more source
Toward transmasculine-inclusive addiction psychiatry in India: a call for research. [PDF]
Babu A +3 more
europepmc +1 more source
A vacuum‐free, ambient‐spray Ni–Cu(–O)/Ag nanowire transparent‐heater platform is realized via conformal junction‐shell engineering and silica–hybrid overcoating, enabling robust high‐temperature heating together with GHz‐band far‐field EMI shielding and near‐field magnetic‐noise attenuation.
Ye Na Heo +4 more
wiley +1 more source

