Results 41 to 50 of about 189,493 (316)
Understanding the Pattern of Cognitive Decline in GBA1‐Related Parkinson's Disease: An Exploratory Longitudinal Multi‐Cohort Study
Annals of Neurology, EarlyView.Objective
People with Parkinson's disease (PD) who carry a pathogenic GBA1 variant (PDGBA1) are at higher risk of cognitive impairment than those without the variant (PDGBA1_wildtype). To date, little is known about the pattern and evolution of cognitive decline in PDGBA1. This multicenter study characterized the cognitive profile of PDGBA, focusing on Merle Bode, Claire Pauly, Sonja Rós Jónsdóttir, Claudia Schulte, Sara Becker, Isabel Wurster, Benjamin Roeben, Stefanie Lerche, Werner Poewe, Rejko Krüger, Inga Liepelt‐Scarfone, Kathrin Brockmann, on behalf of the NCER‐PD consortium, the Parkinson's Progression Markers Initiative, Kenneth Marek, Tanya Simuni, Andrew Siderowf, Caroline Tanner, Thomas F. Tropea, Tatiana Foroud, Lana Chahine, Brit Mollenhauer, Kalpana Merchant, Douglas Galasko, Christopher Coffey, Kathleen Poston, Roseanne Dobkin, Ethan Brown, Roy Alcalay, Dan Weintraub, Emily Flagg, Kimberly Fabrizio, Susan Bressman, Cornelis Blauwendraat, Paola Casalin, Sonya Dumanis, Raymond James, Karl Kieburtz, Sneha Mantri, Werner Poewe, Michael Schwarzschild, John Seibyl, David Standaert, Duygu Tosun‐Turgut, Sohini Chowdhury, Jamie Eberling, Mark Frasier, Leslie Kirsch, Katie Kopil, Maggie Kuhl, Alyssa O’Grady, Todd Sherer, Tawny Willson, Emily Flagg, Tanya Simuni, Bridget McMahon, Craig Stanley, Kim Fabrizio, Dixie Ecklund, Christine Kohnen, Tatiana Foroud, Laura Heathers, Christopher Hobbick, Gena Antonopoulos, John Seibyl, Kathleen Poston, Christopher Coffey, Chelsea Caspell‐Garcia, Michael Brumm, Arthur Toga, Karen Crawford, Tatiana Foroud, Jan Hamer, Brit Mollenhauer, Doug Galasko, Kalpana Merchant, Andrew Singleton, Tatiana Foroud, Dirk Keene, Ethan Brown, Carlie Tanner, Ethan Brown, Lana Chahine, Roseann Dobkin, Monica Korell, Neha Prakash, Tanya Simuni, Nabila Dahodwala, Caroline Tanner, Lana Chahine, Brit Mollenhauer, Sebastian Schade, Douglas Galasko, Anat Mirelman, Roy Alcalay, Katherine Leaver, Marie Saint‐Hilaire, Ruth Schneider, Christopher Tarolli, Werner Poewe, Aleksandar Videnovic, David Standaert, Marissa Dean, Sonja Jonsdottir, Rejko Krueger, Claire Pauly, Stewart Factor, Penelope Hogarth, Robert Hauser, Amy Amara, Michelle Fullard, Cyrus Zabetian, Hubert Fernandez, Kathrin Brockmann, Isabel Wurster, Yen Tai, Paolo Barone, Marina Picillo, Stuart Isaacson, Alberto Espay, Eduardo Tolosa, Javier Ruiz Martinez, Leonidas Stefanis, Kelvin Chou, Lorraine Kalia, Connie Marras, David Grimes, Tiago Mestre, Rajesh Pahwa, Mark Lew, Holly Shill, Shyamal Mehta, Giulietta Riboldi, Nikolaus McFarland, Ron Postuma, Zoltan Mari, David Ledingham, Nicola Pavese, Michele Hu, Norbert Brueggemann, Christine Klein, Bastiaan Bloem, Cristina Simonet, Alastair Noyce, Anette Janzen, David Pedrosa, Wolfgang Oertel, Njideka Okubadejo, David Shprecher, Arjun Tarakad, Emile Moukheiber, Joy Antala, Carla Aranda, Karen Williams, Sophia Melton, Karina Benson, Ashwini Ramachandran, Danielle Potts, Grace LaMoure, Ritikha Vengadesh, Ryan Manzler, Jaime Heller, Primi Ranola, Farah Kausar, Sherri Mosovsky, Diana Willeke, Elizabeth Kalinkara Gomez, Janelle Rodriguez, Nobuko Kemmotsu, May Eshel, Deborah Raymond, Abigail Desrosiers, Raymond James, Lauren Jackson, Iris Egner, Wesley Schlett, Courtney Blair, Lauren Ruffrage, Berenice Sevilla, Barbara Sommerfeld, Dustin Le, Erica Botting, Gabriella Mazur, Daniele Derlein, Evan Doll, Ying Liu, Ciera Cobb, Olivia Masiewicz, Jennifer Mule, Michael Morsillo, Ella Hilt, Aldazier Jakiran, Dominga Valentino, Lisbeth Pennente, Bobbie Stubbeman, Alicia Garrido, Valeria Ravasi, Ioana Croitoru, Christos Koros, Nikolas Papagiannakis, Frank Ferrari, Mengyu Zheng, Shawna Reddie, Alicia Alejandra, Andrea Gray, Alejandra Valenzuela, Caitlin Goodman, Sara Dresler, Neil Santos, Fahrial Esha, Kyle Rizer, Nadine Zablith, Liliana Dumitrescu, Debra Galley, Victoria Kate Foster, Jamil Razzaque, Madita Grümmer, Yara Krasowski, Natalie Donkor, Elisabeth Sittig, Oluwadamilola Ojo, Kelly Clark, Rory Mahabir, Kori Ribb, Shamera Willoughby, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlann, Anne Grünewald, Armin Rauschenberger, Clarissa P. C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez De Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby. +345 morewiley +1 more sourceVerfolgung von Strukturellen Verzerrungen und Orbitalbesetzung während Spin Crossover Prozessen in Metallkomplexen mittels Liganden K‐Kanten Spektroskopie
Angewandte Chemie, EarlyView.Stickstoff‐K‐Kanten XAS‐ und RIXS‐Messungen zeigen Signaturen struktureller und elektronischer Relaxation während der photoinduzierten Spin Crossover‐Kaskade von Eisen‐(II)‐Tris(Bipyridin). Oszillationen der 1s→π∗$1s\rightarrow \pi ^*$ Übergangsenergie stehen in Zusammenhang mit der Änderung der Fe‐N‐Bindungslänge.Sebastian Eckert, Benjamin E. Van Kuiken, Andre Al Haddad, Vinícius Vaz da Cruz, Wagner Ribeiro da Silva Neto, Leo Cordsmeier, Annette Pietzsch, Mattis Fondell, Yi‐Ping Chang, Natalia Gerasimova, Justine Schlappa, Robert Carley, Giuseppe Mercurio, Teguh Citra Asmara, Cammille Carinan, Gregor Knopp, Kirsten Schnorr, Xinhua Xie, Antoine Sarracini, Jonas Knurr, Eloisa F. Manetti, Suddhasattwa Mandal, Loïc L. C. Bassement, Christoph Bostedt, Andreas Scherz, Alexander Föhlisch +25 morewiley +1 more sourceGerma‐Michael Addition: Substratbreite, Mechanismus und Zugang zu Biokompatiblen Wasserlöslichen Typ‐I‐Photoinitiatoren
Angewandte Chemie, EarlyView.Wir beschreiben die erste Germa‐Michael‐Addition zur Synthese eines wasserlöslichen Germanium‐Photoinitiators mit hoher Initiierungseffizienz, Stabilität und geringer Zytotoxizität. Ein NHS‐Ester eröffnet Möglichkeiten zur Biokonjugation, während doppelte Additionen das Funktionalisierungsspektrum erweitern.Matthias Paris, David Vorcnik, Renata Raptova, Mathias Wiech, Nils Ansmann, Zizheng Zhang, Ana Torvisco, Roland C. Fischer, Christine Bandl, Julia Fuchs, Dagmar Brislinger, Lutz Greb, Georg Gescheidt, Michael Haas +13 morewiley +1 more sourceDie tRNA‐Modifikation Geranyl‐2‐thiouridin ermöglicht eine RNA‐Lipid Assoziation
Angewandte Chemie, EarlyView.Wir berichten über die Herstellung mono‐ bis tri‐geranylierter RNA und über die Assoziation hydrophober RNA mit Membranen für einen künftigen effizienten Einbau von RNA in Liposomen. ZUSAMMENFASSUNG
Die Verpackung von RNA in Lipid‐Nanopartikeln zum Schutz und Transport war für die Entwicklung von mRNA‐Impfstoffen und Medikamenten entscheidend.Johannes Singer, Kathrin Halter, Chun‐Yin Chan, Thomas Carell +3 morewiley +1 more sourceTracing Structural Distortions and Orbital Population During Spin‐Crossover in Transition Metal Complexes via Ligand K‐edge Spectroscopy
Angewandte Chemie International Edition, EarlyView.Nitrogen K‐edge XAS and RIXS reveal signatures of structural and electronic relaxation in the photo‐induced spin‐crossover cascade of iron‐(II)‐tris(bipyridine). Oscillations of the 1s→π∗$1{\rm s} \rightarrow \pi ^*$ transition energy are correlated with the transient elongation of the Fe─N bonds.Sebastian Eckert, Benjamin E. Van Kuiken, Andre Al Haddad, Vinícius Vaz da Cruz, Wagner Ribeiro da Silva Neto, Leo Cordsmeier, Annette Pietzsch, Mattis Fondell, Yi‐Ping Chang, Natalia Gerasimova, Justine Schlappa, Robert Carley, Giuseppe Mercurio, Teguh Citra Asmara, Cammille Carinan, Gregor Knopp, Kirsten Schnorr, Xinhua Xie, Antoine Sarracini, Jonas Knurr, Eloisa F. Manetti, Suddhasattwa Mandal, Loïc L. C. Bassement, Christoph Bostedt, Andreas Scherz, Alexander Föhlisch +25 morewiley +1 more source
