Results 121 to 130 of about 3,914,635 (307)

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Angela Pluda. «Infeliçe e sventuratta coca Querina»

Quaderni Veneti
Recensione di Pluda, A. (a cura di) (2019). «Infeliçe e sventuratta coca Querina». I racconti originali del naufragio dei Veneziani nei mari del Nord. Roma: Viella, 100 pp. Interadria – Culture dell’Adriatico 21.
Crifò, Francesco
doaj   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

ON HISTORICAL (ANTI‐)REALISM

History and Theory, EarlyView.
ABSTRACT The problem of historical realism has gained some new momentum recently, with a fresh challenge to what is taken to be an anti‐realist hegemony in the theory and philosophy of history. Unfortunately, this has also provided the opportunity for the reheating of old polemics and lazy scholarship that characterized the 1990s reaction to ...
João Ohara
wiley   +1 more source

Toxic Masculinity: An Outcome of Colonialism and its Effects on the Latinx/Chicanx LGBTQ+ Community [PDF]

, 2019
This research examines masculinity in the Latinx community within the U.S. Much of the theory behind masculinity involves discussing toxic masculinity and machismo.
Martinez, Monica
core   +1 more source

Steppe and the Volga-Kama Finns and Ugrians: issues of contacts in the second half of the I millennium AD in archaeological interpretation (using the example of belt sets)

Археология евразийских степей
Based on the results of research by T.B. Nikitina and N.B. Krylasova on the typology and chronology of the belt set from burial grounds of the VIII–XIII centuries in the Vyatka-Vetluga interfluve (ancient Mari people) and the Middle Kama region (Finno ...
Vladimir A. Ivanov
doaj   +1 more source

What Trina Taught Me: Reflections on Mediation, Inequality, Teaching and Life [PDF]

, 1997
Trina Grillo and I trained together as mediators, met together as law teachers, commiserated together as women and civil rights activists, and laughed and cried together as friends.
Menkel-Meadow, Carrie
core   +2 more sources

SUPERSTITIONS REGARDING THE PROCESS OF PREPARATION FOR WEDDING IN THE BRITISH, RUSSIAN, AND MARI CULTURE

Journal of International Scientific Researches, 2018
Ekaterina Fliginsikh
semanticscholar   +1 more source

Bureaucratic Caring in Action: Chief Nursing Officers' Leadership in Healthcare

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore how chief nursing officers perceive and enact their leadership within bureaucratic healthcare systems, with a particular focus on patient safety, strategic responsibilities and the advancement of nursing care quality. Methods A qualitative study design was used.
Marie Häggström, Lilly‐Mari Sten, Pernilla Ingelsson, Ingela Bäckström, Ulla Näppä   +4 more
wiley   +1 more source

Introduction : gender and geopolitics in the Eurovision Song Contest [PDF]

, 2015
From the vantage point of the early 1990s, when the end of the Cold War not only inspired the discourses of many Eurovision performances but created opportunities for the map of Eurovision participation itself to significantly expand in a short space of ...
Baker, Catherine
core