Results 11 to 20 of about 7,113,628 (317)
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
European Journal of Heart Failure, 2022 Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator) (Netherlands), P. Christian Schulze (CPG Review Coordinator) (Germany), Magdy Abdelhamid (Egypt), Victor Aboyans (France), Stamatis Adamopoulos (Greece), Stefan D.T. McDonagh, M. Metra, M. Adamo, R. Gardner, A. Baumbach, M. Böhm, H. Burri, J. Butler, J. Čelutkienė, O. Chioncel, J. Cleland, A. Coats, M. Crespo-Leiro, D. Farmakis, M. Gilard, S. Heymans, A. Hoes, T. Jaarsma, E. Jankowska, M. Lainščak, C. Lam, A. Lyon, J. McMurray, A. Mebazaa, R. Mindham, C. Muneretto, Massimo Francesco Piepoli, S. Price, G. Rosano, F. Ruschitzka, Anne Kathrine Skibelund +30 moresemanticscholar +1 more sourceThe NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims
The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat +14 morewiley +1 more sourceEnhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos +18 morewiley +1 more sourceInterleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims
Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree +19 morewiley +1 more sourceThree-year Efficacy and Safety of Takeda’s Dengue Vaccine Candidate (TAK-003)
Clinical Infectious Diseases, 2021 Background Takeda’s live attenuated tetravalent dengue vaccine candidate (TAK-003) is under evaluation in a long-term clinical trial across 8 dengue-endemic countries.Luis Rivera, S. Biswal, X. Sáez-Llorens, H. Reynales, Eduardo López-Medina, C. Borja-Tabora, L. Bravo, C. Sirivichayakul, P. Kosalaraksa, Luis Martinez Vargas, Delia Yu, V. Watanaveeradej, Félix Espinoza, R. Dietze, L. Fernando, P. Wickramasinghe, Edson Duarte Moreira, A. Fernando, D. Gunasekera, K. Luz, Rivaldo Venâncio da Cunha, M. Rauscher, O. Zent, Mengya Liu, Elaine Hoffman, I. Lefevre, Vianney Tricou, D. Wallace, M. T. Alera, A. Borkowski +29 moresemanticscholar +1 more source5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)
Annals of Oncology, 2020 F. Cardoso, S. Paluch-Shimon, E. Senkus, G. Curigliano, M. S. Aapro, F. André, C. H. Barrios, J. Bergh, G. S. Bhattacharyya, L. Biganzoli, F. Boyle, M.-J. Cardoso, L. A. Carey, J. Cortés, N. S. El Saghir, M. Elzayat, A. Eniu, L. Fallowfield, P.F. Cardoso, S. Paluch-Shimon, E. Senkus, G. Curigliano, M. Aapro, F. André, C. Barrios, J. Bergh, G. Bhattacharyya, L. Biganzoli, F. Boyle, M. Cardoso, L. Carey, J. Cortes, N. E. El Saghir, M. Elzayat, A. Eniu, L. Fallowfield, P. Francis, K. Gelmon, J. Gligorov, R. Haidinger, N. Harbeck, X. Hu, B. Kaufman, R. Kaur, B. Kiely, S. Kim, N. Lin, S. Mertz, S. Neciosup, B. Offersen, S. Ohno, O. Pagani, A. Prat, F. Penault-Llorca, H. Rugo, G. Sledge, C. Thomssen, D. Vorobiof, T. Wiseman, B. Xu, L. Norton, A. Costa, E. Winer +44 moresemanticscholar +1 more sourceFerric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial.
The Lancet, 2020 BACKGROUND
Intravenous ferric carboxymaltose has been shown to improve symptoms and quality of life in patients with chronic heart failure and iron deficiency.P. Ponikowski, B. Kirwan, S. Anker, T. McDonagh, M. Dorobanțu, J. Drożdż, V. Fabien, G. Filippatos, U. Göhring, A. Keren, I. Khintibidze, H. Kragten, F. Martinez, M. Metra, D. Miličić, J. Nicolau, M. Ohlsson, A. Parkhomenko, D. Pascual-Figal, F. Ruschitzka, D. Sim, H. Skouri, P. Meer, B. Lewis, J. Comín-Colet, S. Haehling, A. Cohen-Solal, N. Danchin, W. Doehner, H. Dargie, M. Motro, J. Butler, T. Friede, K. Jensen, S. Pocock, E. Jankowska, G. Azize, A. Fernandez, Gómez Zapata, P. Pacho, A. Glenny, F. F. Pacora, ML Parody, J. Bono, C. Beltrano, A. Hershson, N. Vita, H. Luquez, HG Cestari, H. Fernandez, A. Prado, M. Berli, R. Durán, J. Thierer, M. Diez, L. Marquez, R. Borelli, M. Hominal, M. Metra, P. Ameri, P. Agostoni, A. Salvioni, L. Fattore, E. Gronda, S. Ghio, F. Turrini, M. Uguccioni, M. Biase, M. Piepoli, S. Savonitto, A. Mortara, P. Terrosu, A. Fucili, G. Boriani, P. Midi, E. Passamonti, F. Cosmi, P. Meer, P. Bergen, M. V. D. Wetering, N. Al-Windy, W. Tanis, M. Meijs, R. Groutars, H. Thè, B. Kietselaer, H. V. Kesteren, D. Beelen, J. Heymeriks, R. V. D. Wal, J. Schaap, M. Emans, P. Westendorp, P. Nierop, R. Nijmeijer, O. Manintveld, M. Dorobanțu, D. Dărăbanțiu, D. Zdrenghea, D. Toader, L. Petrescu, C. Militaru, D. Crișu, M. Tomescu, G. Stanciulescu, A. Dan, L. Iosipescu, DL Serban, J. Drożdż, J. Szachniewicz, M. Bronisz, A. Tycińska, B. Wożakowska-Kapłon, E. Mirek-Bryniarska, M. Gruchała, J. Nessler, E. Straburzyńska-Migaj, K. Mizia-Stec, R. Szełemej, R. Gil, M. Gasior, I. Gotsman, M. Halabi, M. Shochat, M. Shechter, V. Witzling, R. Zukermann, Y. Arbel, M. Flugelman, T. Ben-Gal, V. Zvi, W. Kinany, J. Weinstein, S. Atar, S. Goland, D. Miličić, D. Horvat, S. Tusek, M. Udovičić, K. Šutalo, A. Samodol, K. Pesek, M. Artuković, A. Ružić, J. Šikić, T. McDonagh, J. Trevelyan, Y. Wong, Diana A Gorog, R. Ray, S. Pettit, S. Sharma, A. Kabir, H. Hamdan, L. Tilling, L. Baracioli, L. Maia, Ó. Dutra, G. Reis, P. P. Filho, J. Saraiva, A. Kormann, F. D. Santos, L. Bodanese, D. Almeida, D. Précoma, S. Rassi, F. Costa, S. Kabbani, K. Abdelbaki, C. Abdallah, M. Arnaout, R. Azar, S. Chaaban, O. Raed, G. Kiwan, B. Hassouna, A. Bardají, J. Zamorano, S. D. Prado, J. Juanatey, FI Ga Bosa Ojeda, M. G. Bueno, B. Molina, DA Pascual Figal, D. Sim, TJ Yeo, S. Loh, D. Soon, M. Ohlsson, JG Smith, S. Gerward, I. Khintibidze, Z. Lominadze, G. Chapidze, N. Emukhvari, G. Khabeishvili, V. Chumburidze, K. Paposhvili, T. Shaburishvili, O. Parhomenko, I. Kraiz, O. Koval, V. Zolotaikina, Y. Malynovsky, I. Vakaliuk, L. Rudenko, V. Tseluyko, M. Stanislavchuk +208 moresemanticscholar +1 more sourceNuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Nature, 2010 Innate immunity provides the first line of defence against invading pathogens and provides important cues for the development of adaptive immunity. Type-2 immunity—responsible for protective immune responses to helminth parasites and the underlying cause D. R. Neill, S. Wong, A. Bellosi, R. Flynn, M. Daly, Theresa K.A. Langford, C. Bucks, C. Kane, P. Fallon, R. Pannell, H. Jolin, A. McKenzie +11 moresemanticscholar +1 more source
