Results 111 to 120 of about 36,770 (260)

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Looking at a Blind Spot: Using a Longitudinal Population Cohort Study to Examine Inequalities in Child Social Worker Contact Among Mothers Experiencing Domestic Abuse in Scotland

Child &Family Social Work, EarlyView.
ABSTRACT Research on inequalities in children's services in the UK highlights a lack of systematic data on parental demographics, obstructing analysis of structural factors influencing children's outcomes. Using Growing Up in Scotland, a nationally representative longitudinal child cohort study of children born in 2004–2005, we investigate social ...
Valeria Skafida, Eve Mullins, John Devaney   +2 more
wiley   +1 more source

Parents With Substance Use Disorder in the Holding Tight Treatment System: Intervention Effectiveness and Moderating Effects

Child &Family Social Work, EarlyView.
ABSTRACT Parents with substance use disorder have multiple risks affecting their parenting. Mental health problems and adverse childhood experiences (ACEs) with problems in emotion regulation and adult attachment insecurity may impair the early interaction with the infant.
Saara J. Salo, Marjo Flykt, Yan Li, Mirjam Kalland, Marjukka Pajulo   +4 more
wiley   +1 more source

‘We Are the Eyes on the Streets’—Modes of Proactive Youth Outreach

Child &Family Social Work, EarlyView.
ABSTRACT There is an increasing emphasis on the need for more prevention initiatives targeting the rise of mental health issues, addiction and crime in the youth population across Europe. Youth outreach work has a long‐standing tradition of working with marginalized youth; however, youth culture is dynamic, and there has been limited research in the ...
Ingunn Skjesol, Kristin B. Ørjasæter, Carina Henriksen, Guro Øydgard   +3 more
wiley   +1 more source

Living in Temporary Care: Children's Experiences of Placement Instability in Out‐of‐Home Care—A Thematic Synthesis of a Scoping Review

Child &Family Social Work, EarlyView.
ABSTRACT Placement stability is a central objective in out‐of‐home care, yet many children experience repeated re‐placements. While previous research has largely focused on predictors and outcomes of placement instability, children's own experiences of transient care trajectories remain less explored.
Marian Ådnanes, Vibeke Krane, Ketil Eide, Jannike Kaasbøll, Reidun Follesø, Silje L. Kaspersen, Moses Deyegbe Kuvoame, Mari Gunnes   +7 more
wiley   +1 more source

Oral Status in Relation to Demographic, Socioeconomic, Medical and Psychosocial Risk Factors Among Outpatients in Addiction Treatment Centers, Stockholm, Sweden

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To investigate oral status in relation to demographic, socioeconomic, medical and psychosocial risk factors among outpatients receiving treatment for Substance Use Disorder (SUD). Methods This cross‐sectional study included 91 outpatients from Stockholm, Sweden. Oral status was assessed using the Decayed, Missing, Filled Teeth (DMFT)
Sonja Rafat, Stefan Borg, Gunnar Edman, Anders Hammarberg, Patricia De Palma   +4 more
wiley   +1 more source

The Decentralization of Liquor Policies in Texas During the Post‐Prohibition Era

International Economic Review, EarlyView.
ABSTRACT We examine the decentralization of liquor policies in Texas during the Post‐Prohibition era using newly collected historical legislative roll call data. By combining these data with local referendum vote shares, we analyze both legislators' and constituents' preferences on liquor policy.
Andrew Arnold, Holger Sieg
wiley   +1 more source

Exploring the Impacts of Housing Instability on Intimate Partner Violence, Adverse Health and Risk Behaviours Among Women

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To examine associations between housing instability and intimate partner violence (IPV) exposure, adverse mental health, sexually transmitted infection (STI) and HIV incidence, and substance use among women across the U.S. and its territories. Design Cross‐sectional analysis of data from the American Women: Assessing Risk Epidemiologically
Claudia L. Michaels, Jianfang Liu, Jean Jimenez, Maeve Brin, Nancy Glass, Amy K. Johnson, Mirjam‐Colette Kempf, Rebecca Schnall   +7 more
wiley   +1 more source

The mediating role of motives in the associations between the big five personality traits and marijuana outcomes: A cross-national study across four countries. [PDF]

Addict Behav Rep
Mezquita L, Bravo AJ, Pilatti A, Vidal-Arenas V, Ortet G, Ibáñez MI, Cross-Cultural Addictions Study Team.   +6 more
europepmc   +1 more source