Results 271 to 280 of about 2,868,823 (335)

Deep Learning Approaches for Classifying Crack States With Overload and Predicting Fatigue Parameters in a Titanium Alloy

open access: yesAdvanced Intelligent Systems, EarlyView.
This study proposes a deep learning approach to evaluate the fatigue crack behavior in metals under overload conditions. Using digital image correlation to capture the strain near crack tips, convolutional neural networks classify crack states as normal, overload, or recovery, and accurately predict fatigue parameters.
Seon Du Choi   +5 more
wiley   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

open access: yesAngewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara   +4 more
wiley   +2 more sources

Intelligent Operator‐Independent Flexibility in Robotic Non‐Destructive Evaluation

open access: yesAdvanced Intelligent Systems, EarlyView.
Non‐destructive evaluation of high‐value components remains a manufacturing bottleneck due to rigid robotic calibration and fixturing. This study presents a flexible, adaptable system integrating 3D vision and force‐position control with a collaborative KUKA LBR robot. The geometry‐agnostic system enables pose‐independent ultrasonic inspection, detects
Amine Hifi   +11 more
wiley   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

open access: yesAngewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Advances and Challenges in Micro/Nanocarrier‐Based Dermal Drug Delivery Systems for Acne Treatment

open access: yesAdvanced NanoBiomed Research, EarlyView.
Topical acne treatment faces challenges from skin barriers and complex causes. Micro/nanocarriers improve drug delivery by enhancing bioavailability, targeting, and duration. Combining carriers creates synergistic effects for systematic intervention.
Jintao Yang   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy