Results 181 to 190 of about 183,767 (299)

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

GnRH Regulates Sex Differentiation in <i>Sebastes schlegelii</i> Through TGF-β/MAPK Signaling Pathways. [PDF]

Biology (Basel)
Huang J, Xu P, Xiao Y, Li J.
europepmc   +1 more source

Marine Biology [PDF]

Nature, 1918
openaire   +1 more source

“It's Not Deterministic and It Will Never Be Deterministic”: A Qualitative Study on Stakeholder Perspectives of Polygenic Risk Score Testing for Post‐Traumatic Stress Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Post‐traumatic stress disorder (PTSD) causes significant mental and physical distress, yet only a small subset of individuals exposed to trauma develop the disorder. Scientists and clinicians are still unable to predict who will get the disorder or how it will manifest.
Brandy M. Fox
wiley   +1 more source

AND‐Logic‐Gated Aptamer Switch for Precise Targeting and Regulation of RNA G‐Quadruplexes

Angewandte Chemie, EarlyView.
An AND‐logic‐gated aptamer switch enables tumor‐selective activation of RNA G‐quadruplex (rG4)‐targeting function. By combining cell‐surface recognition and intracellular redox sensing, the system achieves precise regulation of disease‐relevant RNA structures exclusively in tumor cells, with minimal off‐target effects in normal cells, offering a ...
Dan Wang, Ying Feng, Chun Kit Kwok
wiley   +2 more sources

Integrating deep learning, biological hierarchies, and high-resolution imagery to create a new identification tool for cryptic coral reef fishes. [PDF]

PLoS One
Reginato LF, Brandl SJ.
europepmc   +1 more source

Spinal Involvement in a Pediatric and Adult Cohort of Patients With Arthrogryposis Multiplex Congenita

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT This was a single‐center retrospective observational study with national recruitment from October 2007 to March 2022 at the AMC clinic of the University Hospital Grenoble Alpes (CHUGA). Participants underwent a clinical spinal assessment and spine radiography.
Alicia Mom, Véronique Bourg, Shenhao Dai, Alicia‐Marine Milot, Dominic Perennou, Klaus Dieterich   +5 more
wiley   +1 more source

Uncovering Aggregation‐Induced Emission in Carbon Dots for Color‐Changing Hydrogels and Information Encryption

Angewandte Chemie, EarlyView.
Red‐emissive carbon dots (R‐CDs) exhibiting aggregation‐induced emission (AIE) and aggregation‐caused quenching (ACQ) effects are synthesized from citric acid and urea. They display weak blue fluorescence in water but strong red emission in DMF due to aggregation.
Jiafeng Wan, Shiyi Chen, Haopu Su, Tim Muschik, Tongtong Cui, Yosuke Akae, Dominik Voll, Christian W. Schmitt, Stefan Bräse, Tao Chen, Andreas‐Neil Unterreiner, Patrick Théato   +11 more
wiley   +2 more sources

Spatial Differentiation and Driving Mechanisms of Nekton Community Diversity in Eastern Guangdong Coastal Waters, Northern South China Sea. [PDF]

Biology (Basel)
Li Y, Tong M, Zheng X, Tang QH, Zhang YP, Guo YS, Wang ZD, Liao J.   +7 more
europepmc   +1 more source

Marine Biology [PDF]

Nature, 1917
openaire   +1 more source