Results 41 to 50 of about 3,717,965 (289)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Proceedings in Marine Biology [PDF]

, 2021
“Proceedings in Marine Biology” is an international journal publishing original research by graduate students on all aspects of marine biology. Subjects covered include: ecological surveys and population studies of oceanic, coastal and shore communities;
Ehlers, Sarah, Ebel, Roy, Kasper, Leonard, Parsi-Pour, Parima, Schaal Moreno, Guillem, Dressler, Lena Elisa, Raaz, Lion Vincent A.   +6 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Industry-led awards 2018. Marine Institute Grant Awards in Support of the Marine Economy. [PDF]

, 2019
Innovation 2020, Ireland’s strategy for research and development, science and technology states that despite the importance of research and innovation for firms, firms under-invest in research.
Marine Institute
core   +1 more source

Roving Divers Surveying Fish in Fixed Areas Capture Similar Patterns in Biogeography but Different Estimates of Density When Compared With Belt Transects

Frontiers in Marine Science, 2020
Fish abundance and diversity are core measurements taken by many nearshore marine monitoring projects. The most common approaches for counting fish include belt transects and timed counts by roving divers, each with its own limitations.
A. Rassweiler, A. K. Dubel, G. Hernan, D. J. Kushner, J. E. Caselle, J. L. Sprague, L. Kui, T. Lamy, S. E. Lester, R. J. Miller   +9 more
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Marine Institute's Monitoring Programme for Contaminants in Fish and Shellfish [PDF]

, 2006
The Marine Institute monitors the levels of priority hazardous substances in a range of commercial fish species landed at Irish ports and also in shellfish from selected sites around the Irish coast.Funder: Marine ...
Marine Institute
core   +1 more source

Evaluation of local potential-based local marine biology field practicum program

Bio-Inoved: Jurnal Biologi-Inovasi Pendidikan, 2023
Marine biology field practicum based on local potential is routinely held at the Department of Biology Education, Faculty of Teacher Training and Education, University of Borneo Tarakan, but has never been evaluated.
Nur Fitriana Sam, Nursia Nursia, Permadi Burhanuddin   +2 more
doaj   +1 more source