Results 201 to 210 of about 3,839,942 (399)

Engineering a Virus‐Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis

open access: yesAdvanced Science, EarlyView.
In this study, a Faustovirus‐derived polymerase (FvPolX) is engineered based on structural and sequence analysis of PolX enzymes. The optimal mutants demonstrate substantially enhanced catalytic activity toward dNTPs and 3′‐ONH2‐dNTPs compared to the wild‐type enzyme.
Chengjie Zhang, Lei Du, Shengying Li
wiley   +1 more source

Liver Kinase B1 in CD11c+ Cells Inhibits Fibrosis in Chronic Pancreatitis via the Oncostatin M Signaling

open access: yesAdvanced Science, EarlyView.
This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang   +10 more
wiley   +1 more source

Bioinspired Morphology‐Decoupled Soft Gripper with Enhanced Bidirectional Grasping Capability

open access: yesAdvanced Science, EarlyView.
Inspired by biological predation, a novel gripper decouples cross‐modal grasping via dual morphological configurations. Synergistically integrating hybrid rigid and soft coupled fingers with a metamaterial palm, the system performs active compliant grasping for static objects and passive cage capture for dynamic targets.
Yedong Huang   +4 more
wiley   +1 more source

A Large‐Area Broadband Multimodal Dual‐Resonant Haptic Device for Bidirectional Telerobotic and Augmented Interactions

open access: yesAdvanced Science, EarlyView.
We present a large‐area bidirectional human–machine interface integrating electrostatic multimodal tactile sensing with a dual‐resonant haptic actuator. The system enables linear pressure sensing that is decoupled from actuation and stable broadband vibrotactile feedback under dynamic contact conditions, supporting real‐time feedback modulation aligned
Jihun Son   +16 more
wiley   +1 more source

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