Results 11 to 20 of about 872,384 (113)

Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure–Activity Relationships [PDF]

Angewandte Chemie International Edition, 2015
Abstract The bengamides, sponge‐derived natural products that have been characterized as inhibitors of methionine aminopeptidases (MetAPs), have been intensively investigated as anticancer compounds. We embarked on a multidisciplinary project to supply bengamides by fermentation of the terrestrial myxobacterium M.
Wenzel, Silke C, Hoffmann, Holger, Zhang, Jidong, Debussche, Laurent, Haag-Richter, Sabine, Kurz, Michael, Nardi, Frederico, Lukat, Peer, Kochems, Irene, Tietgen, Heiko, Schummer, Dietmar, Nicolas, Jean-Paul, Calvet, Loreley, Czepczor, Valerie, Vrignaud, Patricia, Mühlenweg, Agnes, Pelzer, Stefan, Müller, Rolf, Brönstrup, Mark   +18 more
openaire   +4 more sources

Diversity of myxobacteria isolated from Weizhou Island, Guangxi, and their potential biological activities [PDF]

Archives of Biological Sciences
This study investigated the diversity of cultivable marine myxobacteria from Weizhou Island in the Beibu Gulf of Guangxi, with a particular focus on strains exhibiting potential antibacterial activity and associated enzyme production.
Meng Kangting, Jiang Wang, Cai Huimin, Yang Zhaoming, Yuan Yiran, Su Zhiwei   +5 more
doaj   +2 more sources

Different strategies of osmoadaptation in the closely related marine myxobacteria Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1

Microbiology, 2016
Only a few myxobacteria are known to date that are classified as marine, owing to their salt dependency. In this study, the salt tolerance mechanism of these bacteria was investigated. To this end, a growth medium was designed in which the mutated Escherichia coli strain BKA13 served as sole food source for the predatory, heterotrophic myxobacteria ...
Jamshid Amiri, Moghaddam, Nils, Boehringer, Amal, Burdziak, Hans-Jörg, Kunte, Erwin A, Galinski, Till F, Schäberle   +5 more
openaire   +3 more sources

Diversity of Myxobacteria—We Only See the Tip of the Iceberg

Microorganisms, 2018
The discovery of new antibiotics is mandatory with regard to the increasing number of resistant pathogens. One approach is the search for new antibiotic producers in nature.
Kathrin I. Mohr
doaj   +2 more sources

Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics

Marine Drugs, 2018
Over the last two decades, halophilic (organisms that thrive at high salt concentrations) and halotolerant (organisms that have adapted to high salt concentrations) myxobacteria emerged as an important source of structurally diverse secondary metabolites
Ronald Garcia, James J. La Clair, Rolf Müller   +2 more
doaj   +2 more sources

Genomic insights into novel predatory myxobacteria isolated from human feces [PDF]

Microbiology Spectrum
Myxobacteria are Gram-negative, spore-forming predatory bacteria isolated from diverse environmental samples that feed on other microbes for their survival and growth. However, no reports of cultured representatives from the human gut have been published
Joyasree Das, Shilpee Pal, Anu Negi, Shiva S. Sundharam, Amit Yadav, Srikrishna Subramanian, S. K. Sinha, Jayanta Samanta, Srinivasan Krishnamurthi   +8 more
doaj   +2 more sources

Isolation and Biosynthetic Analysis of Haliamide, a New PKS-NRPS Hybrid Metabolite from the Marine Myxobacterium Haliangium ochraceum

Molecules, 2016
Myxobacteria of marine origin are rare and hard-to-culture microorganisms, but they genetically harbor high potential to produce novel antibiotics. An extensive investigation on the secondary metabolome of the unique marine myxobacterium Haliangium ...
Yuwei Sun, Tomohiko Tomura, Junichi Sato, Takashi Iizuka, Ryosuke Fudou, Makoto Ojika   +5 more
doaj   +2 more sources

Evolution of the Short Enantioselective Total Synthesis of the Unique Marine Myxobacteria Polyketide Salimabromide

Chinese Journal of Chemistry
Comprehensive SummarySalimabromide, a unique and scarce marine tetracyclic polyketide, was synthesized in both racemic and optically active forms. A novel carboxylic acid‐directed method for tandem oxidative difunctionalization of olefins was developed, whereby the formation of bridged butyrolactone and enone moieties occurs concurrently.
Kang‐Ji Gan, Yao Zhu, Gaosheng Shi, Changhui Wu, Fu‐Qiang Ni, Li‐Han Zhao, Xiaowei Dou, Zhihan Zhang, Hai‐Hua Lu   +8 more
openaire   +2 more sources

Comprehensive Insights into Potential Metabolic Functions of Myxococcota in Activated Sludge Systems. [PDF]

Microbes Environ
Myxobacteria, belonging to the phylum Myxococcota, are ubiquitous in soil, marine, and other environments. A recent metagenomic sequencing analysis showed that Myxococcota are predominant in activated sludge systems; however, their metabolic traits ...
Kurashita H, Hatamoto M, Tomita S, Yamaguchi T, Narihiro T, Kuroda K.   +5 more
europepmc   +2 more sources

Enabling Access to Novel Bacterial Biosynthetic Potential From ONT Draft Genomic Data. [PDF]

Microb Biotechnol
We demonstrated that a draft genome assembly obtained using long‐read sequencing is enough for the bioprospection of BGCs, and that it allowed us to successfully clone a novel lanthipeptide BGC into a genome engineering‐ready vector, illustrating the capabilities of this strategy for the discovery of novel natural products.
Campos-Magaña MA, Martins Dos Santos VAP, Garcia-Morales L.   +2 more
europepmc   +2 more sources