Bioassay-Guided Purification of Cytotoxic Isoflavonoids and Sesquiterpenoids of <i>Streptomyces coelicolor</i> Isolated from Marine Sponge <i>Axinella sinoxea</i>, and <i>In Silico</i> Target Prediction. [PDF]
Alborz M +5 more
europepmc +1 more source
One new tyramine derivative (1) and 28 known compounds (2–29) were isolated from deep‐sea‐derived fungus Talaromyces wortmannii. Their structures were elucidated by NMR/MS and computational calculations. Compounds 2 and 6 potently inhibited ferroptosis with EC5₀ values of 4.52 and 13.73 µM.
Ke‐Xin Ma +5 more
wiley +1 more source
Pseudovibriamides from <i>Pseudovibrio</i> marine sponge bacteria promote flagellar motility via transcriptional modulation. [PDF]
Dai Y +7 more
europepmc +1 more source
A broadly applicable synthetic platform based on a DOS/LOS‐like strategy is implemented for the case of sp3‐enriched isoxazole/isoxazoline building blocks. The method is based on a [3+2] cycloaddition of nitroalkanes and various alkenes or alkynes. The utility of the proposed approach is illustrated by the discovery of JAK2‐selective inhibitors.
Bohdan A. Chalyk +12 more
wiley +1 more source
The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa. [PDF]
Hadisaputri YE +8 more
europepmc +1 more source
SiC/Si ceramic hollow fibres: A new approach to Chlorella vulgaris biomass harvesting
Abstract Efficient harvesting of microalgae is a critical challenge for the viability of biorefineries, requiring technologies that combine high selectivity, low cost, and scalability. The current work evaluated the performance of an asymmetric hollow fibre ceramic membrane (HF‐SiC70Si30), fabricated by phase inversion and sintered at 1250°C, in the ...
Erisson Paulo Borges Lopes +4 more
wiley +1 more source
Discovery and Folding Dynamics of a Fused Bicyclic Cysteine Knot Undecapeptide from the Marine Sponge Halichondria bowerbanki. [PDF]
Zhong W +9 more
europepmc +1 more source
Exercise‐Induced Myonectin Protects Against Cerebral Ischemia–Reperfusion Injury
Exercise‐induced myonectin protects against cerebral ischemia–reperfusion injury. Myonectin knockout abolishes exercise benefits, whereas recombinant administration reduces cerebral infarct size. Mechanistically, myonectin activates PI3K/AKT/mTOR signaling, thereby suppressing excessive neuronal autophagy and microglial‐driven neuroinflammation ...
Jing Zhang +7 more
wiley +1 more source
Microbiome changes through the ontogeny of the marine sponge Crambe crambe. [PDF]
Turon M +5 more
europepmc +1 more source
AI‐assisted identification of stromatoporoids
AI models integrating vertical and transverse thin‐section images accurately classify Silurian stromatoporoid taxa, achieving up to 97% accuracy. This dual‐orientation framework mirrors traditional taxonomy, reveals patterns of morphological continuity, and provides a scalable, quantitative approach for advancing automated fossil identification ...
David Rodríguez González +3 more
wiley +1 more source

