Results 141 to 150 of about 12,648 (308)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

O (ne)nadležnosti suda i upravnog tijela

Poredbeno Pomorsko Pravo, 2013
U radu se autori bave dilemom da li je za određivanje naknade za izvlaštenu nekretninu, koja postaje opće dobro – pomorsko dobro, nadležan sud ili upravno tijelo. Na kraju daju svoje viđenje rješenja problema.
Jakob Nakić, Loris Rak
doaj  

Radiation Resilient Synthetic Antiferromagnets‐Based Neuromorphic Device for Sea Surface Temperature Reconstruction

Advanced Science, EarlyView.
By leveraging strong antiferromagnetic coupling, radiation‐tolerant synthetic antiferromagnetic synaptic devices are developed. Their intrinsic nonlinearity emulates neuronal activation, while linear and symmetric conductance modulation mimics synaptic plasticity.
Mingxu Song, Jiahao Liu, Ruisheng Hu, Teng Xu, Aihua Tang, Zhihong Zhu   +5 more
wiley   +1 more source

Stjecanje i zaštita posjeda na pomorskom (općem) dobru de lege lata - de lege ferenda : (poseban osvrt na prijedlog novog Zakona o pomorskom dobru i morskim lukama)

Poredbeno Pomorsko Pravo, 2010
Pomorsko dobro, kao opće dobro, prema općoj normativi Zakona o vlasništvu i drugim stvarnim pravima, te posebnoj normativi Zakona o pomorskom dobru i morskim lukama, predstavlja stvar izvan prometa, koja tako ne može biti objektom prava vlasništva i ...
Ante Perkušić, Ranka Petrinović, Zvonimir Perkušić   +2 more
doaj  

Degradation Pathways of Silicon‐Based Anodes in Lithium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Silicon‐based anodes undergo degradation through five primary pathways: (1) mechanical and structural deterioration of the active material, (2) loss of electrode integrity and electrical contact, (3) mechanical instability of the solid electrolyte interphase (SEI), characterized by repetitive fracture and deformation, (4) chemical instability of the ...
Yoon Jeong Choi, Ji‐Youn Bae, Ga‐On Park, Seung‐Ho Yu   +3 more
wiley   +1 more source

A Quantitative Lithium Inventory Framework for Anode‐Free Lithium Metal Batteries

Advanced Energy Materials, EarlyView.
A component‐resolved lithium inventory framework quantitatively tracks Li redistribution across the cell in anode‐free NMC622||Cu pouch cells throughout cycling. Three sequential degradation stages are identified: formation‐driven cathode Li depletion, midlife inactive Li0 accumulation, and late‐stage runaway SEI thickening. The cathode, as the sole Li
Wurigumula Bao, Alex Liu, Thomas S. Marchese, Yuanlong Bill Zheng, Weikang Li, Dhevathi Rajan Rajagopalan Kannan, Vallabha Rao Rikka, Vinay Premnath, Judith Jeevarajan, Ying Shirley Meng   +9 more
wiley   +1 more source

Problematika stečajnih postupaka nad dioničkim društvima koja obavljaju djelatnost na pomorskom dobru

Poredbeno Pomorsko Pravo, 2016
Cilj ovoga rada je istražiti detaljnije vrlo složenu problematiku stečajnih postupaka nad dioničkim društvima koja obavljaju djelatnost na pomorskom dobru u Republici Hrvatskoj.
Ante Vuković
doaj