Results 171 to 180 of about 42,796 (299)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Advances and prospects of genomic-assisted breeding in roots, tubers, and banana crops. [PDF]

Front Plant Sci
Agre PA, Uwimana B, Nkouaya Mbanjo EG, Ferguson M, Bhattacharjee R, Nyine M, Banda V, Peteti P, Mouritala S, Ismail KS, Amah D, Kolombia Y, Batte M, Tripathi JN, Nakato V, Shah T, Swennen R, Asfaw A, Ismail RY, Tripathi L, Mushoriwa H.   +20 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Genome association of carbohydrate metabolites provides new insights toward functional breeding in coffee. [PDF]

Plant Genome
Tavares Flores E, Spicer RL, Souza EMR, Ferrão MAG, Senra JFB, Azevedo C, Munoz PR, Tieman D, Voiniciuc C, Ferrão LFV.   +9 more
europepmc   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

A breeding strategy for high-oleic acid content and high-yield peanut using Tag SNPs and genomic selection. [PDF]

BMC Plant Biol
Guo M, Miao J, Li Y, Yin J, Wang P, Luo F, Li S, Hu J, Liu W, Zhang T, Ren L, Deng L.   +11 more
europepmc   +1 more source

Marker-Assisted Selection (MAS): A Fast-Track Tool in Tomato Breeding

, 2019
Michael K. Osei, Ruth Prempeh, Joseph Adjebeng-Danquah, Jacinta A. Opoku, Agyemang Danquah, Eric Danquah, Essie Blay, Hans Adu-Dapaah   +7 more
openaire   +2 more sources

Mapping traits of agronomic interest in kiwifruit and development of markers for Markers assisted selection (MAS)

, 2017
In kiwifruit, dioecy and intraspecific polyploidy are great challenges in breeding and cultivar improvement. Marker-assisted selection (MAS) can enhance the selection efficiency and precision in kiwifruit breeding. The prerequisite to MAS is the construction of a high-density linkage map allowing linkage association between marker loci and quantitative
openaire   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source