Results 91 to 100 of about 98,724 (252)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Perceived Stress From Childhood to Adulthood and Cardiometabolic End Points in Young Adulthood: An 18‐Year Prospective Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We investigated how childhood‐to‐adulthood perceived stress patterns predict adult cardiometabolic risk. Methods and Results This study included 276 participants from the Southern California Children's Health Study (2003–2014), and a follow‐up
Fangqi Guo, Xinci Chen, Steve Howland, Phoebe Danza, Zhongzheng Niu, W. James Gauderman, Rima Habre, Rob McConnell, Mingzhu Yan, Lora Whitfield, Yanjie Li, Howard N. Hodis, Carrie V. Breton, Theresa M. Bastain, Shohreh F. Farzan   +14 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The Senescence Marker p16 in Development, Adulthood, and Aging

Le marqueur de sénescence p16Ink4a dans le développement, l'âge adulte et le vieillissement Le vieillissement est une caractéristique biologique qui se caractérise par une dégénérescence progressive de la fonction des cellules, des tissus, des organes ou d'un organisme intact en raison de l'accumulation de facteurs environnementaux et ...
openaire   +2 more sources

Perceived Markers of Adulthood in the Peri-Urban Areas of Nairobi, Kenya

The University Journal
Research on emerging adulthood and markers of adulthood continues to grow worldwide. However, extensive research is yet to be conducted among African populations. The purpose of this study was to understand the markers of adulthood that young people aged 18-29 years in the Nairobi Metropolitan Region of Kenya consider to be important, to assess whether
Anne Muchiri-Muchai, Charity Wangui Waithima, Jeffrey Jensen Arnett   +2 more
openaire   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Lifetime air pollution exposure from prenatal to 18 years and cardiovascular health in young adulthood: findings from a UK birth cohort

Environment International
Aims: We assessed the association between air pollution from pregnancy (in utero) to 18 years and cardiovascular health markers in early adulthood. Methods: Data from 3,767 individuals from a UK birth cohort were used.
Ana Goncalves Soares, Kate Tilling, Maryam Makanvand, Jules Kerckhoffs, Anna L Hansell, Nicholas J Timpson, Ahmed Elhakeem   +6 more
doaj   +1 more source