Results 31 to 40 of about 730,410 (266)
Whole transcriptome profiling of taste bud cells
Scientific Reports, 2017 Analysis of single-cell RNA-Seq data can provide insights into the specific functions of individual cell types that compose complex tissues. Here, we examined gene expression in two distinct subpopulations of mouse taste cells: Tas1r3-expressing type II ...
Sunil K. Sukumaran +5 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Oncology and Therapy, 2023 Introduction Extrapolating long-term overall survival (OS) from shorter-term clinical trial data is key to health technology assessment in oncology. However, extrapolation using conventional methods is often subject to uncertainty.
Stephen Palmer +12 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Remote Sensing, 2020 In this study, the specific differential phase ( K d p ) is applied to attenuation correction for radar reflectivity Z H and differential reflectivity Z D R , and then the corrected Z H , Z D R , and K d p
Guang Wen +2 more
doaj +1 more source
SSRN Electronic Journal, 2005 The existence of a "bidding market" is commonly cited as a reason to tolerate the creation or maintenance of highly concentrated markets. We discuss three erroneous arguments to that effect: the "consultants' fallacy" that "market power is impossible," the "academics' fallacy" that (often) "market power does not matter," and the "regulators' fallacy ...
openaire +2 more sources
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
A Gaussian mixture method for specific differential phase retrieval at X-band frequency [PDF]
Atmospheric Measurement Techniques, 2019 The specific differential phase Kdp is one of the most important polarimetric radar variables, but the variance σ2(Kdp), regarding the errors in the calculation of the range derivative of the differential phase shift Φdp, is not well characterized due to
G. Wen, N. I. Fox, P. S. Market
doaj +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
IEEE Access, 2023 With the rapid advancement of digital technology, artificial intelligence has ushered in a digital society. In this era, digital literacy has become a prerequisite for individuals, as its absence can lead to new vulnerabilities and inequalities ...
Xingyu Chen +5 more
doaj +1 more source