Advanced Science, EarlyView.Non‐invasive low‐intensity pulsed ultrasound ‐triggered cavitation of clinically approved diagnostic‐grade microbubbles delivers favorable mechanical stimuli to renal microvasculature. This intervention restores renal microvascular homeostasis, alleviates DKD‐associated histological and functional damage, and suppresses inflammatory and fibrotic ...
Yubo Lai +8 more
wiley +1 more source
Impact of changes in regulatory framework on approval of medicines for rare diseases and applicability to market access policies. [PDF]
Front Med (Lausanne)Brown F +4 more
europepmc +1 more source
Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors
Advanced Science, EarlyView.Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici +4 more
wiley +1 more source
Primary endpoint acceptance and its association with benefit ratings and market access in German health technology assessments: a retrospective cohort study. [PDF]
Lancet Reg Health EurMüller G, Granold M, Busse R, Hahn A.
europepmc +1 more source
Advanced Science, EarlyView.Across scientific, technological, commercial, and pharmacological domains, individuals and organizations disengage from a previously adopted practice not at random, but as their network neighbors detach. The probability of detachment rises with the number of neighbors who have already disengaged. Preferential detachment reshapes network disintegration,
Binglu Wang +5 more
wiley +1 more source
Access in all areas? A round up of developments in market access and health technology assessment: part 7. [PDF]
J Comp Eff ResRamagopalan SV, Pannelay AJ.
europepmc +1 more source
Advanced Science, EarlyView.This review elucidates the catalytic mechanisms of single‐atom catalysts (SACs) in accelerating lithium polysulfides redox kinetics. Subsequently, the modifications brought by asymmetric coordination chemistry and dual‐atom coordination structures in terms of geometric configuration engineering, molecular orbital hybridization, and interfacial charge ...
Peng Chen +7 more
wiley +1 more source
Customer Retention in the Philippine Food Sector: Health Measures, Market Access, and Strategic Adaptation After the COVID-19 Pandemic. [PDF]
FoodsGumasing MJJ.
europepmc +1 more source
An Integrated Artificial Intelligence Framework for Nanomedicine Engineering
Advanced Science, EarlyView.This review outlines a closed‐loop AI ecosystem for nanomedicine engineering. By synergizing multimodal data harmonization, objective‐driven AI architectures, and automated high‐throughput validation, this “Design‐Make‐Test‐Analyze” (DMTA) workflow transforms traditional heuristic formulation into a predictive, self‐optimizing paradigm, accelerating ...
Meichen Dong +10 more
wiley +1 more source
Market Access Challenges and Solutions in Cell and Gene Therapy in The Netherlands. [PDF]
J Mark Access Health PolicyVelikanova R +4 more
europepmc +1 more source