Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
JUCars-2024: A dataset of used car listings in Jordan. [PDF]
Thalji N, Tahat K.
europepmc +1 more source
Electrolyte Additive Strategies in Aqueous Zn‐Ion Batteries: Recent Advances and Prospects
This article provides a comprehensive overview of the current status and future development directions of AZIBs electrolyte additives in three aspects: stabilizing zinc anodes (uniform deposition, inhibition of dendritic crystals), protecting cathodes (structural stability, inhibition of dissolution), and enhancing electrolyte stability (wider ...
Yuanze Yu +7 more
wiley +1 more source
Justification trajectories for pension inequality in Chile (2016-2023): the role of social class and beliefs in meritocracy. [PDF]
Castillo JC +3 more
europepmc +1 more source
The ultrathin (2.5 nm) MXene film self‐assembled at liquid interfaces breaks the trade‐off between transparency (82.5 %) and photothermal conversion effect (DT∼25.1°C ± 2.9 °C) under 100 mW cm−2. After encapsulated by a slippery surface with low adhesion, this transparent film can be applied in smart windows, eyewear, and optical sensors to autonomous ...
Xiao Han +6 more
wiley +1 more source
Economic evaluation of cyclin-dependent kinases 4 and 6 inhibitors in advanced hormonal receptor-positive and human epidermal growth factor receptor 2 negative breast cancer: a nationwide budget impact analysis. [PDF]
Elazzazy S +5 more
europepmc +1 more source
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Analytical Framework to Navigate Microalgae-Based Product Development-Aligning Commercialization and Regulatory Pathways. [PDF]
Tenzin G +6 more
europepmc +1 more source
A dual‐functional Nb2O5 modulation strategy is reported to overcome kinetic limitations in Ni‐rich cathodes. The formation of LiNbO3 phase at the grain boundary of the polycrystalline NCM9055 cathode preserves a radially aligned microstructure and establishes fast lithium‐ion pathways.
Tian Rao +11 more
wiley +1 more source
Facilitators of and barriers to labor market participation among people with acquired deafblindness: A scoping review. [PDF]
Heppe ECM +5 more
europepmc +1 more source

