Results 31 to 40 of about 4,413,794 (283)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Realtime market microstructure analysis: online Transaction Cost Analysis [PDF]

, 2013
Motivated by the practical challenge in monitoring the performance of a large number of algorithmic trading orders, this paper provides a methodology that leads to automatic discovery of the causes that lie behind a poor trading performance.
Azencott, Robert, Beri, Arjun, Gadhyan, Yutheeka, Joseph, Nicolas, Lehalle, Charles-Albert, Rowley, Matthew   +5 more
core  

Volatility return intervals analysis of the Japanese market [PDF]

, 2007
We investigate scaling and memory effects in return intervals between price volatilities above a certain threshold $q$ for the Japanese stock market using daily and intraday data sets. We find that the distribution of return intervals can be approximated
Black, Bunde, Bunde, Bunde, Corral, Cox, Ding, Engle, Engle, F. Z. Wang, Gabaix, Gopikrishnan, Granger, H. E. Stanley, H.-T. Moon, Harris, Kaizoji, Kaizoji, Lillo, Liu, Livina, Mandelbrot, Mantegna, Matteo, Ord, Pagan, Plerou, Plerou, S. Havlin, Sazuka, Scalas, Scalas, Schwert, Stephens, T. Kaizoji, Takayasu, Tsallis, W.-S. Jung, Wang, Weber, Yamasaki   +40 more
core   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Mind the method! A systematic literature review of the methodological choices used to assess the environmental impacts of diets

Cleaner Environmental Systems
Our food system is a major driver of environmental impacts, and a large proportion of these impacts are due to animal-based foods and food loss and waste. In recent years, many studies have been published looking at the environmental impact of our diets,
Yanne Goossens, Thomas G. Schmidt
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Quality Standards and Contractual Terms Affecting Food Losses: The Perspective of Producer Organisations in Germany and Italy

Foods, 2023
With the aim of disclosing the antecedents and dynamics of food loss generation in the upstream stages of the fruit and vegetable sector, this paper presents the results of a series of semi-structured interviews with 10 Producers’ Organisations (POs) in ...
Roberta Pietrangeli, Ronja Herzberg, Clara Cicatiello, Felicitas Schneider   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Clinical burden of invasive Escherichia coli disease among older adult patients treated in hospitals in the United States

BMC Infectious Diseases, 2023
Background Invasive extraintestinal pathogenic Escherichia coli disease (IED) can lead to severe outcomes, particularly among older adults. However, the clinical burden of IED in the U.S. has not been well characterized.
Luis Hernandez-Pastor, Jeroen Geurtsen, Bryan Baugh, Antoine C. El Khoury, Nnanya Kalu, Marjolaine Gauthier-Loiselle, Rebecca Bungay, Martin Cloutier, Michal Sarnecki, Elie Saade   +9 more
doaj   +1 more source

Scaling Analysis on Indian Foreign Exchange Market

, 2005
In this paper we investigate the scaling behavior of the average daily exchange rate returns of the Indian Rupee against four foreign currencies namely US Dollar, Euro, Great Britain Pound and Japanese Yen.
A. Sarkar, Ausloos, Bak, Barat, Dacorogna, Dorogovtsev, Gençay, Grigolini, Guillaume, Hurst, LeBaron, LeBaron, Liu, Mandelbort, Mantegna, Mantegna, Matia, Müller, Nolan, P. Barat, Scafetta, Scafetta, Scafetta, Scafetta, Scafetta, Siebesma, Stanley   +26 more
core   +1 more source