Results 131 to 140 of about 224,956 (288)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

open access: yesAdvanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong   +6 more
wiley   +1 more source

Proposals for a strategic segmentation of the green market

open access: yesManagement Letters/Cuadernos de Gestión, 2002
The increasing ecological concern and the need to attend to the new ecological demand, oblige enterprises to develop analysis tools in order to know better to the ecological consumer.
M. AZUCENA VICENTE MOLINA   +1 more
doaj  

Market Segmentation, Targeting, Dan Brand Positioning Dari Winston Premier Surabaya [PDF]

open access: yes, 2014
Sejak tahun 2012 mulai terasa bahwa bisnis properti mengalami kenaikan di Indonesia. Banyak masyarakat Indonesia berinvestasi pada properti karena dianggap aman dan menguntungkan. Sehingga muncul banyak produk properti baru di Indonesia.
Tania, D. (Debby)
core  

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

open access: yesAdvanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du   +5 more
wiley   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

open access: yesAdvanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su   +15 more
wiley   +1 more source

Optimal Monetary Policy under Asset Market Segmentation [PDF]

open access: yes
This paper studies optimal monetary policy in a small open economy under flexible prices. The paper’s key innovation is to analyze this question in the context of environments where only a fraction of agents participate in asset market transactions (i.e.,
Amartya Lahiri   +2 more
core  

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

open access: yesAdvanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li   +19 more
wiley   +1 more source

CUSTOMER - TARGETED STRATEGY AS A COMPONENT OF MARKETING STRATEGY

open access: yesPolityki Europejskie, Finanse i Marketing, 2013
Total, customer targeted strategy comprises two solutions: marketing stimulation strategy and market segmentation strategy. Marketing stimulation strategy is an aggregate of two main instruments of influence: a broadly understood “set of benefits”, and ...
Marek Rawski
doaj  

FINDINGS OF PRICING-TO-MARKET: MARKET SEGMENTATION OR PRODUCT DIFFERENTIATION? [PDF]

open access: yes
Pricing to market (PTM) has been examined extensively in the recent trade literature using Knetter's (1989) model. The technique is typically applied using export unit values that aggregate differentiated products.
Lavoie, Nathalie, Liu, Qihong
core   +1 more source

PEDOT:PSS—A Key Material for Bioelectronics

open access: yesAdvanced Science, EarlyView.
PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez   +5 more
wiley   +1 more source

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