Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford +3 more
wiley +1 more source
How Have Alcohol Producers Changed the Alcohol Content of Their Products? A Descriptive Analysis of Reformulation in the Off-Trade Alcohol Market in Great Britain, 2018-2025. [PDF]
Angus C +6 more
europepmc +1 more source
Structural Colors from Modulated Topological Defects in Molecular Smectic Liquid Crystals
Rather than using dyes and pigments, nature produces the colors of some butterflies and beetles through optical interference phenomena. This study describes an original biomimetic strategy exploiting the spontaneous formation of modulated linear defects in thin films of 8CB, a common molecular liquid crystal.
Camille N. Mahyaoui +7 more
wiley +1 more source
The Impact of Uncertain Intellectual Property Rights on the Market For Ideas: Evidence From Patent Grant Delays [PDF]
This paper considers the impact of the intellectual property (IP) system on the timing of cooperation/licensing by start-up technology entrepreneurs. If the market for technology licenses is efficient, the timing of licensing is independent of whether IP
Joshua S. Gans +2 more
core
Expanding Quantitative Medicines' Reach: Systems and Methods to Enhance R&D Productivity and Decision-Making in the Agentic-Era. [PDF]
Corrigan BW +8 more
europepmc +1 more source
Phosphorus‐rich MgP4 is introduced as a high capacity anode for sodium‐ion batteries (SIBs) via hybrid carbon matrix engineering. A sequential CNT/G assembly forms a conductive and mechanically robust network, delivering a high reversible capacity of 1386 mAh g−1 while stabilizing alloying reactions.
Sion Ha +6 more
wiley +1 more source
A multi-agent equilibrium model in an incomplete market with discrete dividends: Applications to long-term discount curves. [PDF]
Saito T, Takahashi A.
europepmc +1 more source
Converting CO2 into advanced carbon materials capable of meeting the rapid lithium storage demands of lithium‐ion batteries creates a mutually beneficial scenario for both energy and environmental sectors. Here, we propose a stepwise CO2 electrolysis approach to transform dilute CO2 into interlayer‐expanded graphite using molten salt electrolyzers ...
Hao Zha +8 more
wiley +1 more source
Trends and cross-county disparities in childhood pneumococcal vaccination in Zhejiang Province, China, 2011-2022. [PDF]
Wang Y +8 more
europepmc +1 more source
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong +10 more
wiley +1 more source

