Results 11 to 20 of about 3,853,426 (309)

Systematic literature review of asthma biologic self-administration enhanced by a patient perspective

Journal of Allergy and Clinical Immunology: Global
Background: Several biologics for the treatment of severe asthma are available as self-administration devices. Objective: We performed a systematic literature review to understand the use, benefits, and challenges of these self-administration devices ...
Simona Boccaletti, MSc, Rafael Alfonso-Cristancho, PhD, Waseem Ahmed, MBA, Lehanne Sergison, Adaeze Eze, MSc, Prashant Auti, MS (Pharm), Cathelijne Alleman, MSc, Lohit Badgujar, PhD, Nicholas Halfpenny, MSc, Dorothea Heldt, MSc   +9 more
doaj   +1 more source

Severe haematological toxicities in relapsed ovarian cancer treated with olaparib or niraparib: an Italian cost-minimization analysis

Global & Regional Health Technology Assessment, 2019
The aim of this paper is to compare the cost for managing severe haematological toxicities (HTs: anaemia, neutropenia, thrombocytopenia) in patients with pretreated, relapsed BRCA -mutant positive (+) ovarian cancer (OC) receiving second-line therapy ...
Carlo Lazzaro, Nicola Amedeo Mazzanti, Fabio Parazzini   +2 more
doaj   +1 more source

Urine output is an early and strong predictor of acute kidney injury and associated mortality: a systematic literature review of 50 clinical studies

Annals of Intensive Care
Background Although the present diagnosis of acute kidney injury (AKI) involves measurement of acute increases in serum creatinine (SC) and reduced urine output (UO), measurement of UO is underutilized for diagnosis of AKI in clinical practice.
Manu L. N. G. Malbrain, Krista Tantakoun, Anthony T. Zara, Nicole C. Ferko, Timothy Kelly, Wojciech Dabrowski   +5 more
doaj   +1 more source

Economic Value Added Dan Market Value Added Dampaknya Terhadap Nilai Perusahaan [PDF]

, 2009
The aim of research was to fi nd out an infl uence of Economic Value Added (EVA) andMarket Value Added (MVA) towards share price of PT. International Nickel Indonesia, tbk (PT.INCO).The secondary data was gathered by capital market information centre ...
Mursalim, M. (Mursalim)
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Modelling the potential clinical and economic impact of universal immunisation with nirsevimab versus standard of practice for protecting all neonates and infants in their first respiratory syncytial virus season in Spain

BMC Infectious Diseases
Background Respiratory syncytial virus (RSV) is associated with substantial morbidity among infants. This study modelled the potential public health and economic impact of nirsevimab, a long-acting monoclonal antibody, as an immunoprophylactic strategy ...
Ruth Gil-Prieto, Jaime Jesus Pérez, Georgina Drago, Alexia Kieffer, Julie Roïz, Paulina Kazmierska, Aditya Sardesai, Solène de Boisvilliers, Juan Luis López-Belmonte, Matthieu Beuvelet, Javier Alvarez Aldean   +10 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Mathematical Formulation of an Optimal Execution Problem with Uncertain Market Impact [PDF]

, 2015
We study an optimal execution problem with uncertain market impact to derive a more realistic market model. We construct a discrete-time model as a value function for optimal execution.
Ishitani, Kensuke, Kato, Takashi
core   +3 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source