Results 71 to 80 of about 39,642 (267)

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

Cultural Markets and Consecration

, 2019
Cultural consumer markets are, to a large degree, governed by processes of social stratification, distinction, and the symbolic properties of cultural taste. Especially Bourdieu’s field theory has been influential, but in recent years criticized—often for its emphasis on cultural hierarchies and consecration agents. This chapter argues that it would be
openaire   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

Integrating cultural adaptation in digital marketing strategies: Enhancing competitiveness and sustainability in MSMEs of Java, Indonesia

Journal of Open Innovation: Technology, Market and Complexity
This study explores the critical role of cultural adaptation in digital marketing strategies employed by Micro, Small, and Medium Enterprises (MSMEs) in Java, Indonesia, within the context of a rapidly digitizing marketplace and shifting consumer ...
Marsya Aulia Rizkita, Agung Winarno, Hadi Suwono, Nik Ahmad Nizam Nik Malek   +3 more
doaj   +1 more source

CULTURES WITHIN NATIONAL CULTURES: INTERNATIONAL MARKETING WITHIN THE DOMESTIC MARKETING ENVIRONMENT

Economic Review, 2016
As a result of increasing multiculturalism within countries, even traditionally domestic marketers are beginning to experience similar environmental conditions that were once exclusive to their international marketing counterparts. It would be interesting to examine how groups within the same domestic environments acquire different consumption habits ...
Tantawy, Rasha Y, George, Babu P
openaire   +3 more sources

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Cross-cultural characteristics of international marketing communications on web-site and social media [PDF]

Marketing (Beograd. 1991), 2018
The topic of this paper are cross-cultural specifics of marketing communications on Website and social media. Website is starting point for all activities of a company on Internet.
Mitić Sanja
doaj  

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Promoting Intangible Cultural Heritage Through Universal Marketing Strategies for Tourist Regions

Socio-Cultural Management Journal
Introduction. At the present stage, the issue of updating marketing concepts to promote cultural heritage is considered relevant and of practical importance. Strategies for developing tourist regions currently require innovative upgrades in line with the
Ihor Komarnitskyi, Roman Beshleha, Yurii Bilokon   +2 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source