Results 31 to 40 of about 20,156 (257)
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy
Advanced Science, EarlyView.Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi +12 more
wiley +1 more source
Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR‐T Cell Engineering
Advanced Science, EarlyView.This study compares charge‑neutral and cationic lipidnanoparticles (LNPs) for ex vivo mRNA delivery to T cells, revealing distinctdependencies on medium composition and T cell activation. Where conventional LNPs benefit from ApoE‐dependent T cell targeting, cationic DOTAP‑modified LNPs mediate unspecific charge‑dependent transfection.
Laure Harinck +9 more
wiley +1 more source
Jurnal Manajemen dan Profesional, 2021 The development of the current era of globalization, the use of the internet in obtaining information is very easy. Especially during the Covid-19 Pandemic, almost all community activities are carried out online, starting from government activities, work,
David Chandra Saputra +1 more
doaj +1 more source
, 2010 Konsumenten werden heutzutage von Werbung regelrecht erschlagen. Jeden Tag prasseln tausende von Werbebotschaften auf die Menschen ein. Diese bilden einen natürlichen Widerstand dagegen und nehmen so wenig wie möglich auf, um sich auf wichtige Informationen konzentrieren zu können.
Nufer, Gerd, Schattner, Pascal
openaire +2 more sources
Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Advanced Science, EarlyView.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Investigating the effective factors on electronic trade by viral marketing [PDF]
Management Science Letters, 2014 This paper performs an investigation to explore a number of strategies underpinning virtual marketing. The study also provides several suggestions for marketers seeking to use viral marketing to position brands or to change a brand’s image, to encourage ...
Nina Ghane +3 more
doaj +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Redes sociales y marketing viral: repercusión e incidencia en la construcción de la agenda mediática
Palabra Clave, 2011 DOI: 10.5294/pacla.2011.14.1.3 En este artículo se demuestra cómo el establecimiento de relaciones consolidadas entre los usuarios que participan en los contextos sociales virtuales, y el ejercicio de prácticas vinculadas con el marketing viral, pueden
Miguel Túñez-López +2 more
doaj
Advanced Science, EarlyView.A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park +11 more
wiley +1 more source