Results 111 to 120 of about 146,110 (315)

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

A Bayesian Analysis of Female Wage Dynamics Using Markov Chain Clustering [PDF]

In this work, we analyze wage careers of women in Austria. We identify groups of female employees with similar patterns in their earnings development. Covariates such as e.g.
Christoph Pamminger, Regina Tüchler
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Correction : perfect simulation for a class of positive recurrent Markov chains [PDF]

, 2007
In [1] we introduced a class of positive recurrent Markov chains, named tame chains. A perfect simulation algorithm, based on the method of dominated CFTP, was then shown to exist in principle for such chains. The construction of a suitable dominating
Connor, Stephen B., Kendall, W. S.
core   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

PENERAPAN MODEL MARKOV CHAIN DALAM MEMPREDIKSI KEBERHASILAN STUDI [PDF]

, 1999
Konsep dasar Markov Chain baru diperkenalkan sekitar tahun 1907, oleh seorang Matenlatisi Rusia Andrei A. Markov (1856-1922). Model in; berhubungan dengal?
Abdurachman, Edi
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MCMC-ODPR : primer design optimization using Markov Chain Monte Carlo sampling [PDF]

, 2012
Background Next generation sequencing technologies often require numerous primer designs that require good target coverage that can be financially costly.
Kitchen, James, Kitchen James L, Allaby Robin G, Moore, Jonathan D., Palmer Sarah A, Allaby, Robin G., Moore Jonathan D, Palmer, Sarah A.   +7 more
core   +1 more source

MONTE CARLO MARKOV CHAIN (MCMC) STOCHASTIC MODELING OF SUPPLY CHAIN

Annals: Series on engineering sciences (Academy of Romanian Scientists)
Effective inventory management in multi-echelon supply chains is challenged by stochastic demand and uncertain lead times, which amplify variability and increase operational costs.
Marcel ILIE, Augustin SEMENESCU
doaj   +1 more source

Pregnancy‐related effect on elexacaftor, tezacaftor and ivacaftor pharmacokinetics in women with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas, Naim Bouazza, Frantz Foissac, Saïk Urien, Léo Froelicher‐Bournaud, Gabrielle Lui, Victoria Guillemart, Nicolas Carlier, Jennifer Da Silva, Johanna Fesenbeckh, Reem Kanaan, Isabelle Honoré, Clémence Martin, Jean‐Marc Treluyer, Vassilis Tsatsaris, Pierre‐Régis Burgel, Sihem Benaboud   +16 more
wiley   +1 more source

Markov chain analysis to detect water quality level [PDF]

, 2013
The quantificational analysis on progress of river water quality is important in knowing the dynamic change of water quality level. A mathematical model based on Markov chain is established in order to detect the water quality level in rivers.
Rahman, Nurul Nabihah
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