CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley +1 more source
Research on the value screening of combat rescue information based on the Markov decision tree model. [PDF]
Int J Emerg MedLi X, Li Z, Hao Y, Ma W.
europepmc +1 more source
Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou +4 more
wiley +1 more source
Enhancement of hidden Markov model analyses for improved inference of archaic introgression in modern humans. [PDF]
Mol Biol EvolColl Macià M +3 more
europepmc +1 more source
Impact of Packaging and Recycling Systems on Material Recirculation: A Stage‐Decomposition Model
Packaging Technology and Science, EarlyView.A system‐level view emerges from decomposing recycling into four stages (participation, collection, sorting and process yield), diagnosing constraints and targeting interventions. Cumulative equivalent uses (CEUs) quantify long‐term retention, revealing marginal improvements at high baselines generate disproportionately larger gains than low‐baseline ...
Diogo Figueirinhas +3 more
wiley +1 more source
Assessing spatio-temporal coupling between intangible cultural heritage and rural development in China (2013-2022) through coupling coordination analysis and random-forest prediction. [PDF]
Sci RepDu Y, Wang K, Chen L, Zhou Y.
europepmc +1 more source
Quality and Reliability Engineering International, EarlyView.ABSTRACT A repairable system operates under a maintenance strategy involving scheduled preventive maintenance (PM) and corrective repair actions following failures. This study develops an exact analytical methodology using Markov chains with discrete states and time to calculate the expected number of failures E[N(t)]$\mathop {\mathbb {E}}[N(t)]$ under
Danilo G. O. Valadares +3 more
wiley +1 more source
Research on the regional disparities and dynamic evolution of the coupling coordination level between digital industrialization and industrial digitalization in China. [PDF]
Sci RepRao W, Liu P, Wei C, Jiang S.
europepmc +1 more source
A Rank‐Based CUSUM Monitoring Scheme for Time Between Events and Amplitude Data
Quality and Reliability Engineering International, EarlyView.ABSTRACT Monitoring time between events and amplitude (TBEA) data is critical in many applications, particularly in manufacturing, reliability engineering, and service operations. Yet, most existing TBEA control charts focus on a single quality characteristic and are typically developed under restrictive distributional assumptions.
Muhammad Arslan +5 more
wiley +1 more source
Evaluating the coupling coordination between industrial chains and innovation chains in the construction industry of Western China from a production-manufacturing perspective. [PDF]
Sci RepXu J, Zhang Y, Chen Z.
europepmc +1 more source