Results 251 to 260 of about 771,482 (302)

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou   +4 more
wiley   +1 more source

Impact of Packaging and Recycling Systems on Material Recirculation: A Stage‐Decomposition Model

open access: yesPackaging Technology and Science, EarlyView.
A system‐level view emerges from decomposing recycling into four stages (participation, collection, sorting and process yield), diagnosing constraints and targeting interventions. Cumulative equivalent uses (CEUs) quantify long‐term retention, revealing marginal improvements at high baselines generate disproportionately larger gains than low‐baseline ...
Diogo Figueirinhas   +3 more
wiley   +1 more source

Brown–Proschan Repair Policy for Repairable Systems Using the Discrete Weibull Failure Distribution and Markov Chains

open access: yesQuality and Reliability Engineering International, EarlyView.
ABSTRACT A repairable system operates under a maintenance strategy involving scheduled preventive maintenance (PM) and corrective repair actions following failures. This study develops an exact analytical methodology using Markov chains with discrete states and time to calculate the expected number of failures E[N(t)]$\mathop {\mathbb {E}}[N(t)]$ under
Danilo G. O. Valadares   +3 more
wiley   +1 more source

A Rank‐Based CUSUM Monitoring Scheme for Time Between Events and Amplitude Data

open access: yesQuality and Reliability Engineering International, EarlyView.
ABSTRACT Monitoring time between events and amplitude (TBEA) data is critical in many applications, particularly in manufacturing, reliability engineering, and service operations. Yet, most existing TBEA control charts focus on a single quality characteristic and are typically developed under restrictive distributional assumptions.
Muhammad Arslan   +5 more
wiley   +1 more source

Integrating Image Segmentation and Deep Learning to Improve Radio Frequency Propagation Models

open access: yesInternational Journal of Satellite Communications and Networking, EarlyView.
ABSTRACT This paper proposes a multi‐sensor approach to improve radio frequency (RF) propagation models, which play a key role in the rapidly expanding field of connected vehicle technology. Focusing on the 1‐ to 20‐GHz frequency range, which is critical for both satellite‐to‐vehicle and base station‐to‐vehicle communications, our study introduces a ...
Jonathan Israel   +2 more
wiley   +1 more source

Energy Dependence, Energy Import Diversification, and Institutional Quality: Heterogeneous Impacts on Sustainable Economic Development in the European Union

open access: yesSustainable Development, EarlyView.
ABSTRACT Energy dependence poses significant risks for economic development, particularly in regions that rely heavily on imported fossil fuels. This paper examines how energy dependence and energy import diversification influence economic development across 27 European Union countries between 2000 and 2022. Using IV‐GMM and panel quantile regressions,
Mehmet Pinar
wiley   +1 more source

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