Results 141 to 150 of about 810,691 (251)

Strong differentiation between source and ex situ populations of rare plant species revealed by next‐generation sequencing

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is being lost rapidly worldwide due to factors such as climate change and habitat loss. To help safeguard plant populations, conservation strategies include seed banks and conservation cultures. However, it remains unclear how cultivation affects genetic variation compared with wild populations.
Maximilian Alexander Steurer, Ellen Gradl, Lena Winkler, Christoph Reisch   +3 more
wiley   +1 more source

Floristic condition drives differential response to cultural burns in grassy woodlands for ectomycorrhizal and arbuscular mycorrhizal fungi

PLANTS, PEOPLE, PLANET, EarlyView.
Cultural burns are a critical Indigenous land management practice with diverse cultural and biodiversity benefits, now being reintroduced by Indigenous communities to Australian grassy woodlands after long post‐colonization suppression. How these burns influence soil fungi, critical partners in plant nutrition, remains poorly understood.
Solomon Maerowitz‐McMahan, Elle J. Bowd, Dean Freeman, Rachael H. Nolan, Adam Frew, Jeff R. Powell   +5 more
wiley   +1 more source

Theory and inference for a Markov switching GARCH model [PDF]

We develop a Markov-switching GARCH model (MS-GARCH) wherein the conditional mean and variance switch in time from one GARCH process to another. The switching is governed by a hidden Markov chain. We provide sufficient conditions for geometric ergodicity
ROMBOUTS, Jeroen V.K., PREMINGER, Arie, BAUWENS, Luc   +2 more
core   +2 more sources

Supervised Protein Structure Classification Using Topological Persistence With DeltaFold

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Recent advances in protein structure prediction have considerably increased the number of available structures, underscoring the need for scalable and accurate methods to compare and classify this huge amount of data. Current approaches based on sequence alignment or structural superposition often lack sensitivity and/or are computationally ...
Joseph Nardin‐Gennequin, Gabriela Ciuperca, Céline Brochier‐Armanet, Philippe Malbos   +3 more
wiley   +1 more source

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

Information‐Theoretic Framework for Allosteric Communication Pathway Prediction From Protein Structure

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Allosteric communication is fundamental to the function of proteins, but identifying the residue‐level pathways through which signals travel and their directionality is still a major challenge. Here we present a multi‐metric information‐theoretic framework that identifies candidate allosteric communication pathways from a single protein ...
Aysima Hacisuleyman, Dirk Fasshauer
wiley   +1 more source

A Simulation-Free Topological Basis for Building Compact Koopman Models of Protein Folding. [PDF]

J Chem Inf Model
Fakhoury Z, Sosso GC, Habershon S.
europepmc   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Behavioural state inference from movement and environmental data using Markovian step selection functions. [PDF]

PLoS One
Bouderbala I, Nicosia A, Fortin D.
europepmc   +1 more source

Evaluation of BLAST-based edge-weighting metrics used for homology inference with the Markov Clustering algorithm. [PDF]

BMC Bioinformatics, 2015
Gibbons TR, Mount SM, Cooper ED, Delwiche CF.   +3 more
europepmc   +1 more source