Results 181 to 190 of about 725,754 (336)

Reinforcement Learning for Robust Dynamic Metabolic Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Dynamic metabolic control allows key metabolic fluxes to be modulated in real time, enhancing bioprocess flexibility and expanding available optimization degrees of freedom. This is achieved, for example, via targeted modulation of metabolic enzyme expression.
Sebastián Espinel‐Ríos, River Walser, Dongda Zhang   +2 more
wiley   +1 more source

Multistate Markov model for functional recovery in stroke: probability of state transition and prognosis prediction. [PDF]

Sci Rep
Li B, Wan C.
europepmc   +1 more source

Mathematical Modeling of Amoxicillin Synthesis in Batch and Semi‐Batch Reactor: Application of Bayesian Statistics and Genetic Algorithm

Biotechnology and Bioengineering, EarlyView.
Synthesis of amoxicillin: The reaction catalyzed by penicillin G acylase is investigated in an enzymatic reactor, considering both Michaelis–Menten and mechanism‐based models with reaction and equilibrium constants. Parameters are estimated via MCMC and Genetic Algorithm, with MCMC showing superior performance in validating the mathematical model in a ...
Lucas Figueiredo Formigosa, Ingrid Cabral dos Santos, Letícia Eduarda Alves e Álvares, Emanuel Negrão Macêdo, Luciana Rocha Barros Gonçalves, Bruno Marques Viegas   +5 more
wiley   +1 more source

Exploring regional air pollution transition dynamics: A multi-state markov model approach. [PDF]

PLoS One
Hossain MI, Sarkar S, Methun MIH, Rahman A.   +3 more
europepmc   +1 more source

The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA

Cancer Communications, EarlyView.
Abstract Background Blood‐based cell‐free DNA (cfDNA) methylation testing has emerged as a promising approach for multi‐cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional bisulfite‐based methods often encounter sensitivity limitations in detecting early‐stage malignancies or certain cancer types.
Hui‐Yan Luo, Wei Wei, Pansong Li, Qi‐Hua Zhang, Zhipeng Zhou, Liang Cui, Yong‐Bin Lin, Hong Yang, Xianyu Zhong, Qingfeng Liu, Han Yang, Kong‐Jia Luo, Hai‐Bo Qiu, Shu‐Qiang Yuan, Yuan‐Fang Li, Zhi‐Wei Zhou, Xiao‐Jun Lin, Bo‐Kang Cui, Rong‐Xin Zhang, Wen‐Hua Fan, He Huang, Chun‐Yan Lan, Jun‐Dong Li, Zhi‐Qiang Wang, Bin‐Kui Li, Rong‐Ping Guo, Jun Tang, Xin Huang, Mian Xi, Yuying Liu, Chuanbo Xie, Shi Chen, Zhi‐Hu Li, Yu‐Hua Liu, Xiao‐Ting Zhang, Qiang Zeng, Xin Yi, Rui‐Hua Xu   +37 more
wiley   +1 more source

Economic evaluation of hypertension screening in Iran using a Markov model. [PDF]

PLoS One
Daroudi R, Sari AA, Zamandi M, Yousefi E.   +3 more
europepmc   +1 more source

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

Health and economic gains from bariatric surgery in Portugal: an in-depth analysis using a Markov model. [PDF]

Health Econ Rev
Cardoso P, Redondo P, Castro P, Sousa J, Fagundes JO.   +4 more
europepmc   +1 more source

Estimating transition rates in aggregated Markov models of ion channel gating with loops and with nearly equal dwell times [PDF]

, 1999
Mirko Wagner, S. Michalek, Jens Timmer
openalex   +1 more source

Automatic parameter update algorithm for regression models to estimate remaining useful life: Application in an offshore natural gas dehydration unit

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Remaining useful life (RUL) analysis of equipment prevents failures and assists in maintenance to address impending failures. To achieve this, the advancement of degradation can be measured through a determinant variable. This work presents a new methodology for estimating the number of remaining cycles (NRC), or RUL, of equipment in cyclic ...
Leonardo M. de Marco, Jorge Otávio Trierweiler, Marcelo Farenzena   +2 more
wiley   +1 more source