Results 261 to 270 of about 725,754 (336)

Slow Expectation–Maximization Convergence in Low‐Noise Dynamic Factor Models

Journal of Applied Econometrics, EarlyView.
ABSTRACT This paper addresses the slow convergence of the expectation–maximization (EM) algorithm in the estimation of low‐noise dynamic factor models, commonly used in macroeconomic nowcasting and forecasting. We show analytically and in Monte Carlo simulations how the EM algorithm stagnates in a low‐noise environment, leading to inaccurate estimates ...
Daan Opschoor, Dick van Dijk
wiley   +1 more source

Using a Markov Model and Real-World Evidence to Identify the Most Cost-Effective Cholesterol Treatment Escalation Threshold for the Secondary Prevention of Cardiovascular Disease. [PDF]

Appl Health Econ Health Policy
Mariani A, Mohiuddin S, Muller P, Samarasekera E, Swain SA, Mills J, Patel R, Preiss D, Shantsila E, Downing BC, Lonergan M, Rowark S, Welton NJ, Williams R, Wonderling D.   +14 more
europepmc   +1 more source

Steiner Triple Systems With High Discrepancy

Journal of Combinatorial Designs, EarlyView.
ABSTRACT In this paper, we initiate the study of discrepancy questions for combinatorial designs. Specifically, we show that, for every fixed r ≥ 3 $r\ge 3$ and n ≡ 1 , 3 ( mod 6 ) $n\equiv 1,3\,(\mathrm{mod}\,6)$, any r $r$‐colouring of the triples on [ n ] $[n]$ admits a Steiner triple system of order n $n$ with discrepancy Ω ( n 2 ) ${\rm{\Omega }}({
Lior Gishboliner, Stefan Glock, Amedeo Sgueglia   +2 more
wiley   +1 more source

Health economic assessment of the Landes public service 'Vivre à Domicile (VIVADOM)' (Living at Home) based on personalised care for frail older adults with human support and digital solutions (telecare, tablet, home automation and connected objects): a Markov model study protocol. [PDF]

BMJ Open
Sawadogo AR, Gayot C, Nys JF, Le Goff-Pronost M, Tchalla A.   +4 more
europepmc   +1 more source

Population Pharmacokinetics of Valemetostat and Exposure–Response Analyses of Efficacy and Safety in Patients with Relapsed/Refractory Peripheral T–Cell Lymphoma

The Journal of Clinical Pharmacology, EarlyView.
Abstract Valemetostat is a dual inhibitor of EZH2/1 approved in Japan for the treatment of relapsed/refractory (R/R) adult T–cell lymphoma/leukemia (ATLL) and R/R peripheral T–cell lymphoma (PTCL). It is administered orally once daily (QD) at 200 mg. Here, we present comprehensive population pharmacokinetic (PPK) and exposure–response (ER) analyses of ...
Hiroyuki Inoue, Xiaoning Wang, Ramon Garcia, Brian Reilly, Masaya Tachibana, YoungJun Yoo, Yvonne Lau, Yang Chen   +7 more
wiley   +1 more source

Last‐minute coordination: Adapting to demand to support last‐mile operations

Journal of Operations Management, Volume 71, Issue 2, Page 176-194, March 2025.
Abstract In the highly competitive e‐commerce industry, customer‐facing warehouses are crucial as the “order penetration points” for e‐commerce last‐mile operations. This research examines how warehouses use last‐minute coordination, an unstructured mechanism, to ensure sufficient inventory at the order penetration points. Previous research has focused
Kedong Chen, Hung‐Chung Su, Kevin Linderman, William Li   +3 more
wiley   +1 more source

A Multistate Continuous Time-Inhomogeneous Markov Model for Assessing the CD4 Count Dynamics of HIV/AIDS Patients Undergoing Antiretroviral Therapy in KwaZulu-Natal, South Africa. [PDF]

Int J Environ Res Public Health
Mashiri CE, Batidzirai JM, Chifurira R, Chinhamu K.   +3 more
europepmc   +1 more source

Last Glacial Maximum and deglacial branched GDGT‐based palaeotemperature reconstruction from a subtropical Australian wetland

Journal of Quaternary Science, EarlyView.
ABSTRACT Future projections of climate change in the subtropics suggest warming and drying, while evidence from warm periods in the past shows increases in subtropical temperatures and precipitation. Eastern Australia is subject to interannual hydroclimate drivers and has experienced extreme flooding and droughts in recent years.
Joan Macalalad, Kevin Welsh, Harald Hofmann, Geraldine Jacobsen, Zhenyu Ni, Enlou Zhang   +5 more
wiley   +1 more source

Intuition–Driven Prospection and Uncertainty Misalignment: Sources of Entrepreneurial Agency Problems in Ventures

Strategic Change, EarlyView.
ABSTRACT Start‐up CEOs are usually more aligned with the interests of the venture board compared to CEOs in legacy firms, and therefore it is usual to conclude that the traditional agency problem is lower in ventures. In this article, it is argued that this is only half of the story, and that the agency problem is reversed in early ventures such that ...
Glenn Kristiansen
wiley   +1 more source