Results 231 to 240 of about 1,483,088 (317)

Bridging Human and Plant Adaptations for Climate Resilience

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Climate change is transforming agriculture through both gradual shifts and increasingly unpredictable extremes, challenging farmers' ability to protect crops and livelihoods. This study brings together farmer experiences and plant adaptation strategies to explore how people and plants respond to similar climate pressures.
Nicola Favretto   +3 more
wiley   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

open access: yesPest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King   +6 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Edge based distributed framework for real time hazard detection and road safety in smart transportation. [PDF]

open access: yesSci Rep
Sahu D   +8 more
europepmc   +1 more source

Impact of Packaging and Recycling Systems on Material Recirculation: A Stage‐Decomposition Model

open access: yesPackaging Technology and Science, EarlyView.
A system‐level view emerges from decomposing recycling into four stages (participation, collection, sorting and process yield), diagnosing constraints and targeting interventions. Cumulative equivalent uses (CEUs) quantify long‐term retention, revealing marginal improvements at high baselines generate disproportionately larger gains than low‐baseline ...
Diogo Figueirinhas   +3 more
wiley   +1 more source

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