Results 111 to 120 of about 131,091 (318)

Alzheimer's Disease Co‐Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objectives Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) share neuropathological features, including tau, amyloid, and TDP‐43 pathology. This study investigated whether AD‐related pathological changes are associated with cognitive impairment ALS. Methods Cerebrospinal fluid (CSF total‐tau, phosphorylated‐tau, beta‐amyloid) and plasma
Elisabeth Kasper   +29 more
wiley   +1 more source

Convergence of stochastic process with Markov switching [PDF]

open access: yesМатематичні Студії, 2012
It has been established sufficient conditions for the convergence of a multi-dimensional stochastic process in the case of dependence of the regression function on the environment, which is described by Markov switchings.
O. I. Kiykovska, Ya. M. Chabanyuk
doaj  

tanggle: An R package for the visualization of phylogenetic networks

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Premise Phylogenetic trees depict evolutionary relationships among taxa. However, they are strictly bifurcating structures that do not take into account several types of evolutionary events such as horizontal gene transfer, hybridization, or introgression. Although the development of new methods in phylogenetic networks has recently increased,
Klaus Schliep   +6 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

open access: yesHepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim   +12 more
wiley   +1 more source

A discrete-time split-state framework for multi-state modeling with application to describing the course of heart disease

open access: yesBMC Medical Research Methodology
In chronic disease epidemiology, the investigation of disease etiology has largely focused on an endpoint, while the course of chronic disease is understudied, representing a knowledge gap. Multi-state models can be used to describe the course of chronic
Ming Ding, Haiyi Chen, Feng-Chang Lin
doaj   +1 more source

Detecting introgression from phylogenetic invariant site patterns using machine learning

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Premise Detecting historical introgression among populations or species from genomic data is a common goal in evolutionary genetics. Most current methods fall into two major categories: network inference and admixture inference. Network inference (e.g., SNaQ) is computationally challenging and typically requires first reducing large genomic ...
Patrick F. McKenzie, Deren A. R. Eaton
wiley   +1 more source

The multiple birth properties of multi-type Markov branching processes

open access: yesBoundary Value Problems
The main purpose of this paper is to consider the multiple birth properties for multi-type Markov branching processes. We first construct a new multi-dimensional Markov process based on the multi-type Markov branching process, which can reveal the ...
Junping Li, Wanting Zhang
doaj   +1 more source

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