Results 251 to 260 of about 557,874 (331)

Population Pharmacokinetics of Valemetostat and Exposure–Response Analyses of Efficacy and Safety in Patients with Relapsed/Refractory Peripheral T–Cell Lymphoma

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Valemetostat is a dual inhibitor of EZH2/1 approved in Japan for the treatment of relapsed/refractory (R/R) adult T–cell lymphoma/leukemia (ATLL) and R/R peripheral T–cell lymphoma (PTCL). It is administered orally once daily (QD) at 200 mg. Here, we present comprehensive population pharmacokinetic (PPK) and exposure–response (ER) analyses of ...
Hiroyuki Inoue   +7 more
wiley   +1 more source

A Markov Chain Replacement Strategy for Surrogate Identifiers: Minimizing Re-Identification Risk While Preserving Text Reuse. [PDF]

open access: yesElectronics (Basel)
Osborne JD   +11 more
europepmc   +1 more source

Last‐minute coordination: Adapting to demand to support last‐mile operations

open access: yesJournal of Operations Management, Volume 71, Issue 2, Page 176-194, March 2025.
Abstract In the highly competitive e‐commerce industry, customer‐facing warehouses are crucial as the “order penetration points” for e‐commerce last‐mile operations. This research examines how warehouses use last‐minute coordination, an unstructured mechanism, to ensure sufficient inventory at the order penetration points. Previous research has focused
Kedong Chen   +3 more
wiley   +1 more source

Last Glacial Maximum and deglacial branched GDGT‐based palaeotemperature reconstruction from a subtropical Australian wetland

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Future projections of climate change in the subtropics suggest warming and drying, while evidence from warm periods in the past shows increases in subtropical temperatures and precipitation. Eastern Australia is subject to interannual hydroclimate drivers and has experienced extreme flooding and droughts in recent years.
Joan Macalalad   +5 more
wiley   +1 more source

Intuition–Driven Prospection and Uncertainty Misalignment: Sources of Entrepreneurial Agency Problems in Ventures

open access: yesStrategic Change, EarlyView.
ABSTRACT Start‐up CEOs are usually more aligned with the interests of the venture board compared to CEOs in legacy firms, and therefore it is usual to conclude that the traditional agency problem is lower in ventures. In this article, it is argued that this is only half of the story, and that the agency problem is reversed in early ventures such that ...
Glenn Kristiansen
wiley   +1 more source

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