Results 41 to 50 of about 4,593 (195)

Identification of a novel corticotropin-releasing hormone type 1 beta-Like receptor variant lacking exon 13 in human pregnant myometrium regulated by estradiol-17 beta and progesterone [PDF]

open access: yes, 2010
Two types of CRH receptors mediate the diverse biological functions of CRH and CRH-related peptides. The type 1 CRH-R (CRH-R1) is extensively targeted by pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.
Jing Chen   +13 more
core   +1 more source

Clinical and Radiometabolic Correlatives of ddPCR Liquid Biopsy for BRAF V600 Mutated Melanoma

open access: yesInternational Journal of Cancer, EarlyView.
Commercial circulating tumor DNA (ctDNA) liquid biopsy tests are increasingly used for disease monitoring and surveillance in melanoma. However, data regarding the possible correlations between ctDNA and baseline clinical and radiometabolic parameters such as metastatic locations, tumor volume, and tumor glycolysis in patients with BRAF‐mutated ...
Ronen Stoff   +8 more
wiley   +1 more source

Western Balkans as the Frontline of Russian Hybrid Warfare

open access: yesGlobal Policy, EarlyView.
ABSTRACT Hybrid warfare (HW) scholarship acknowledges the phenomenon's contextual and temporal specificity, yet its dominant conceptual framing has generated a literature largely centred on identifying and categorising hybrid activities. This focus has left the contextual vulnerabilities that enable hybrid threats (HTs) and shape an adversary's ...
Vesna Bojicic‐Dzelilovic
wiley   +1 more source

Application of Multi‐Method Dating for Understanding the Gravettian North of Moravia, Central Europe

open access: yesArchaeometry, EarlyView.
ABSTRACT This article presents the results of integrating three methods to assess the age of the Upper Palaeolithic site of Pietraszyn 11 (SW Poland), close to the Moravian Gate. Sediment chronology determined using optically stimulated luminescence produced promising, yet ambiguous results (51.0 ± 3.7 to 20.3 ± 0.7 ka).
A. Wiśniewski   +16 more
wiley   +1 more source

Child and school staff perceptions and experiences of universal social and emotional learning curricula in context: A qualitative case study registered report examining ‘Passport Skills for Life’

open access: yesBritish Journal of Educational Psychology, EarlyView.
Abstract Background There is increasing interest in the circumstances under which universal school‐based social and emotional learning (SEL) interventions can be most effective, and how implementation moderates intervention outcomes. We focus on the implementation of ‘Passport Skills for Life’, an SEL intervention that has been introduced into over 100
Ola Demkowicz   +13 more
wiley   +1 more source

Tightening the Bounds on Cache-Related Preemption Delay in Fixed Preemption Point Scheduling

open access: yes, 2017
Limited Preemptive Fixed Preemption Point scheduling (LP-FPP) has the ability to decrease and control the preemption-related overheads in the real-time task systems, compared to other limited or fully preemptive scheduling approaches.
Dobrin, Radu   +5 more
core   +1 more source

An overview of Mass Accumulation Rates in key Polish loess–palaeosol sequences derived from luminescence chronologies

open access: yesBoreas, EarlyView.
Loess–palaeosol sequences (LPS) represent one of the most important continental archives of late Quaternary environmental change in Europe. Establishing reliable chronologies is essential for reconstructing dust dynamics and for correlating regional loess stratigraphies. In this study, we present the first systematically derived mass accumulation rate (
Maksymilian Jędrzejowski   +7 more
wiley   +1 more source

Integrating surface plasmon resonance and slow photon effects in nanoporous anodic alumina photonic crystals for photocatalysis [PDF]

open access: yes, 2019
This study explores the potential of gold-coated titania-functionalized nanoporous anodic alumina distributed Bragg reflectors (Au-TiO2-NAA-DBRs) as platforms to enhance photocatalytic reactions by integrating “slow photons” and surface plasmon resonance
Law, S.   +5 more
core   +1 more source

Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais   +4 more
wiley   +1 more source

Patch Testing in Paediatric Drug Hypersensitivity Reactions: Current Evidence and Clinical Implications

open access: yesContact Dermatitis, EarlyView.
ABSTRACT Drug hypersensitivity reactions (DHRs) are common in children and are diagnostically challenging, with cutaneous manifestations being the most common presentation. Patch testing (PT) is a well‐established tool for investigating delayed T‐cell‐mediated reactions and is widely used in patients with contact dermatitis.
Gabriele Simonetti   +7 more
wiley   +1 more source

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