Identification of a novel corticotropin-releasing hormone type 1 beta-Like receptor variant lacking exon 13 in human pregnant myometrium regulated by estradiol-17 beta and progesterone [PDF]
Two types of CRH receptors mediate the diverse biological functions of CRH and CRH-related peptides. The type 1 CRH-R (CRH-R1) is extensively targeted by pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.
Jing Chen +13 more
core +1 more source
Clinical and Radiometabolic Correlatives of ddPCR Liquid Biopsy for BRAF V600 Mutated Melanoma
Commercial circulating tumor DNA (ctDNA) liquid biopsy tests are increasingly used for disease monitoring and surveillance in melanoma. However, data regarding the possible correlations between ctDNA and baseline clinical and radiometabolic parameters such as metastatic locations, tumor volume, and tumor glycolysis in patients with BRAF‐mutated ...
Ronen Stoff +8 more
wiley +1 more source
Western Balkans as the Frontline of Russian Hybrid Warfare
ABSTRACT Hybrid warfare (HW) scholarship acknowledges the phenomenon's contextual and temporal specificity, yet its dominant conceptual framing has generated a literature largely centred on identifying and categorising hybrid activities. This focus has left the contextual vulnerabilities that enable hybrid threats (HTs) and shape an adversary's ...
Vesna Bojicic‐Dzelilovic
wiley +1 more source
Application of Multi‐Method Dating for Understanding the Gravettian North of Moravia, Central Europe
ABSTRACT This article presents the results of integrating three methods to assess the age of the Upper Palaeolithic site of Pietraszyn 11 (SW Poland), close to the Moravian Gate. Sediment chronology determined using optically stimulated luminescence produced promising, yet ambiguous results (51.0 ± 3.7 to 20.3 ± 0.7 ka).
A. Wiśniewski +16 more
wiley +1 more source
Abstract Background There is increasing interest in the circumstances under which universal school‐based social and emotional learning (SEL) interventions can be most effective, and how implementation moderates intervention outcomes. We focus on the implementation of ‘Passport Skills for Life’, an SEL intervention that has been introduced into over 100
Ola Demkowicz +13 more
wiley +1 more source
Tightening the Bounds on Cache-Related Preemption Delay in Fixed Preemption Point Scheduling
Limited Preemptive Fixed Preemption Point scheduling (LP-FPP) has the ability to decrease and control the preemption-related overheads in the real-time task systems, compared to other limited or fully preemptive scheduling approaches.
Dobrin, Radu +5 more
core +1 more source
Loess–palaeosol sequences (LPS) represent one of the most important continental archives of late Quaternary environmental change in Europe. Establishing reliable chronologies is essential for reconstructing dust dynamics and for correlating regional loess stratigraphies. In this study, we present the first systematically derived mass accumulation rate (
Maksymilian Jędrzejowski +7 more
wiley +1 more source
Integrating surface plasmon resonance and slow photon effects in nanoporous anodic alumina photonic crystals for photocatalysis [PDF]
This study explores the potential of gold-coated titania-functionalized nanoporous anodic alumina distributed Bragg reflectors (Au-TiO2-NAA-DBRs) as platforms to enhance photocatalytic reactions by integrating “slow photons” and surface plasmon resonance
Law, S. +5 more
core +1 more source
Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia
Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais +4 more
wiley +1 more source
ABSTRACT Drug hypersensitivity reactions (DHRs) are common in children and are diagnostically challenging, with cutaneous manifestations being the most common presentation. Patch testing (PT) is a well‐established tool for investigating delayed T‐cell‐mediated reactions and is widely used in patients with contact dermatitis.
Gabriele Simonetti +7 more
wiley +1 more source

