Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie +4 more
wiley +1 more source
Connectivity profile and function of uniquely human cortical areas. [PDF]
J NeurosciBryant KL +7 more
europepmc +1 more source
Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez +15 more
wiley +1 more source
Reviewing Mobile Apps for Teaching Human Anatomy: Search and Quality Evaluation Study.
JMIR Med EducRivera García GE +4 more
europepmc +1 more source
Investigating the Predictive Capabilities of MARS for Biomass Pyrolysis Kinetics: A Case Study on an Oil Palm Empty Fruit Bunch. [PDF]
ACS OmegaAhmad J, Ngamcharussrivichai C, Ali I.
europepmc +1 more source
Heterozygous variants in AP4S1 are not associated with a neurological phenotype
Annals of Clinical and Translational Neurology, EarlyView.Abstract Biallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function. We critically evaluate this claim against clinical observations in 28 heterozygous carriers of the same
Vicente Quiroz +9 more
wiley +1 more source
Utilizing Martian samples for future planetary exploration-Characterizing hazards and resources. [PDF]
Proc Natl Acad Sci U S AWhetsel C +5 more
europepmc +1 more source
Skin calcium deposits in primary familial brain calcification: A novel potential biomarker
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder characterized by small vessel calcifications in the basal ganglia. PFBC is caused by pathogenic variants in different genes and its physiopathology is still largely unknown. Skin vascular calcifications have been detected in single PFBC cases, suggesting
Aron Emmi +8 more
wiley +1 more source
Perspectives on Mars Sample Return: A critical resource for planetary science and exploration. [PDF]
Proc Natl Acad Sci U S AMcSween HY, Hamilton VE, Farley KA.
europepmc +1 more source
Note on the perturbations of (8) Flora by Mars and the earth, and on Brunnow's tables
, 1893 Ashley Hall
openalex +2 more sources