Results 61 to 70 of about 562,958 (314)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mars Dust Storm Sequence Dataset (MDSSD)

, 2022
The Mars Dust Storm Sequence Dataset (MDSSD) contains information on dust storm instances and dust storm sequences manually identified in the Mars Reconnaissance Orbiter (MRO) Mars Color Imager (MARCI) Mars Daily Global Maps (https://doi.org/10.7910/DVN ...
Wang, Huiqun (Helen), Saidel, Morgan, Battalio, Michael J., Toigo, Anthony D., Richardson, Mark, I.   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Is there methane on Mars? [PDF]

Icarus, 2011
Abstract There have been several reports of methane on Mars at the 10–60 ppbv level. Most suggest that methane is both seasonally and latitudinally variable. Here we review why variable methane on Mars is physically and chemically implausible, and then we critically review the published reports.
Zahnle, Kevin J., Freedman, Richard S., Catling, David C.   +2 more
openaire   +1 more source

Habitability on Early Mars and the Search for Biosignatures with the ExoMars Rover

Astrobiology, 2017
The second ExoMars mission will be launched in 2020 to target an ancient location interpreted to have strong potential for past habitability and for preserving physical and chemical biosignatures (as well as abiotic/prebiotic organics).
J. Vago, F. Westall, A. Coates, R. Jaumann, O. Korablev, V. Ciarletti, I. Mitrofanov, J. Josset, M. D. De Sanctis, J. Bibring, F. Rull, F. Goesmann, H. Steininger, W. Goetz, W. Brinckerhoff, C. Szopa, F. Raulin, H. Edwards, L. Whyte, A. Fairén, J. Bridges, E. Hauber, G. Ori, S. Werner, D. Loizeau, R. Kuzmin, Rebecca M. E. Williams, J. Flahaut, F. Forget, D. Rodionov, H. Svedhem, E. Sefton-Nash, G. Kminek, L. Lorenzoni, L. Joudrier, Viktor Mikhailov, A. Zashchirinskiy, Sergei Alexashkin, F. Calantropio, Andrea Merlo, P. Poulakis, O. Witasse, O. Bayle, S. Bayón, U. Meierhenrich, J. Carter, J. García‐Ruiz, P. Baglioni, A. Haldemann, A. Ball, A. Debus, R. Lindner, F. Haessig, D. Monteiro, R. Trautner, C. Voland, P. Rebeyre, D. Goulty, F. Didot, S. Durrant, E. Zekri, D. Koschny, A. Toni, G. Visentin, M. Zwick, M. van Winnendael, M. Azkarate, C. Carreau   +67 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Walking on Mars [PDF]

Nature, 1998
Sometime in the near future humans may walk in the reduced gravity of Mars. Gravity plays an essential role in walking. On Earth, the body uses gravity to ‘fall forwards’ at each step and then the forward speed is used to restore the initial height in a pendulum-like mechanism.
G.A. Cavagna, P. A. Willems, N. C. Heglund   +2 more
openaire   +3 more sources

Cosmic dust fluxes in the atmospheres of Earth, Mars, and Venus

Icarus (New York, N.Y. 1962), 2020
The ablation of cosmic dust injects a range of metals into planetary upper atmospheres. In addition, dust particles which survive atmospheric entry can be an important source of organic material at a planetary surface.
J. Carrillo-Sánchez, J. Gómez-Martín, D. Bones, D. Nesvorný, P. Pokorný, M. Benna, G. Flynn, J. Plane   +7 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source