Results 231 to 240 of about 965,602 (296)

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Mars' induced magnetosphere can form under radial interplanetary magnetic field. [PDF]

Innovation (Camb)
Lin R, Huang S, Zhou J, Wang Y, Yuan Z, Dubinin E, Fränz M, Lu H, Liu K, Chai L, Song Y, Wang G, Chi Y, Wu H, Jiang K, Xiong Q, Zou Z.   +16 more
europepmc   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Rocky Planets as Heat Engines. [PDF]

Space Sci Rev
Lourenço DL, Breuer D, Arnould M, Baumeister P, Bolmont E, Byrne PK, Cawood PA, Coltice N, Duarte JC, Foley B, Gerya T, Karato SI, Miozzi F, Noack L, Revol A, Spohn T, Stern RJ.   +16 more
europepmc   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Evidence of an enhanced near-surface ozone layer at tropical latitudes on Mars. [PDF]

Proc Natl Acad Sci U S A
Viúdez-Moreiras D, Smith MD, Wolff M, Brown MAJ, Daerden F, Zorzano MP, Apestigue V, Arruego I, García E, Jiménez JJ, Toledo D, Lemmon MT, Knutsen EW, Saiz-Lopez A.   +13 more
europepmc   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

The Effect of Vulcanization Temperature on the Network Structure and Properties of TBAF-Functionalized BR/VMQ Blends for Mars Environment Applications. [PDF]

Materials (Basel)
Nizel N, Bieliński DM, Wręczycki J, Maciejewska M, Anyszka R.   +4 more
europepmc   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Sulfur isotope heterogeneity in Martian shergottites reveals early atmosphere - mantle exchange. [PDF]

Commun Earth Environ
Patil K, Dottin JW, Fu H, Monteleone B, Chatterjee N, Hooper N, Izon G, Adams JC, Irving A, Shearer CK, Franz HB, Ono S.   +11 more
europepmc   +1 more source