Results 71 to 80 of about 6,477,182 (276)

Mars exploration program [PDF]

, 1993
An overview of the Mars Exploration Program is presented in outline and graphic form. Mission objectives, mission strategy, operations concept, transportation element, launch vehicle considerations and program schedule are ...
Weary, Dwayne
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mars, The Nearest Habitable World — A Comprehensive Program For Future Mars Exploration [PDF]

Bulletin of the AAS, 2021
Bruce Jakosky, Shane Byrne, Wendy Calvin, Shannon Curry, Bethany Ehlmann, Jen Eigenbrode, Tori Hoehler, Briony Horgan, Scott Hubbard, Tom McCollom, John Mustard, Than Putzig, Michelle Rucker, Michael Wolff, Robin Wordsworth, Michael Meyer, Rich Zurek   +16 more
openaire   +1 more source

Contemporary Legal Challenges in Mars Colonization: a Comprehensive Analytical Review of Regulatory Frameworks (2024–2025)

Московский журнал международного права
INTRODUCTION. The study presents a comprehensive analytical review of legal challenges in Mars colonization, examining the evolution and systemic gaps in international space law.
Ya. E. Brazovskaya, D. M. Avdysh
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Research on main control parameters for LCO2 flash boiling abrasive jet based on ISRU on Mars

Meitan xuebao
Space exploration and extraterrestrial resource extraction have emerged as comprehensive focal points in both major power strategic competition and the building of a shared future for humanity.
Wenchuan LIU, Aotian JIANG, Jiren TANG, Yiyu LU, Zhuoya ZHANG, Jun LI   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

ESA's Mars Program: European Plans for Mars Exploration [PDF]

, 2005
A viewgraph presentation on the European Space Agency Mars Exploration Program is shown. The topics include: 1) History:Mars Exploration in Europe; 2) A few preliminary results from Mars Express; 3) A new instrument:Radar MARSIS; and 4) European Mars ...
Forget, Francois
core  

Continuity and Change in U.S. Space Exploration Approaches (2017–2025)

Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика
In recent years, amid the increasing polarization in American society, the United States has witnessed growing divergences between its key parties on virtually all domestic and foreign policy issues. However, this trend has barely affected U.S.
P. G. Koshkin
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source